Roles and mechanisms of action of pituitary adenylate cyclase-activating polypeptide (PACAP) in growth hormone and prolactin secretion

被引：9
|
作者：
Murakami, Y [1 ]
Koshimura, K [1 ]
Yamauchi, K [1 ]
Nishiki, M [1 ]
Tanaka, J [1 ]
Kato, Y [1 ]
机构：
[1] Shimane Med Univ, Dept Med, Div 1, Izumo, Shimane 6938501, Japan
来源：
ENDOCRINE JOURNAL | 2001年 / 48卷 / 02期
关键词：
D O I：
10.1507/endocrj.48.123
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
It appears that PACAP has a direct action on somatotrophs to release GH. The intracellular signal transduction mechanisms for PACAP might be similar to but partly distinct from those for GRH. PACAP might play a role in GH secretion induced by serotoninergic mechanisms but not in ultradian rhythm of GH secretion in the rat. PACAP can stimulate PRL release from the pituitary in rats possibly through indirect paracrine effect. In addition, PACAP might participate in regulation of PRL secretion via hypothalamic VIP.
引用
收藏
页码：123 / 132
页数：10
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