Iridium-catalyzed asymmetric hydrogenation of unfunctionalized tetrasubstituted Olefins

被引：110
|
作者：
Schrems, Marcus G. [1 ]
Neumann, Eva [1 ]
Pfaltz, Andreas [1 ]
机构：
[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 43期
关键词：
asymmetric catalysis; hydrogenation; iridium; N; P ligands; tetrasubstituted olefins;
D O I：
10.1002/anie.200702555
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Even notoriously unreactive substrates such as tetrasubstituted unfunctionalized olefins can be hydrogenated with high efficiency and excellent enantioselectivity using readily accessible chiral Ir catalysts. In this way, two adjacent stereogenic centers can be introduced in a single step (see scheme for an example; BArF = tetrakis(3,5- di(trifluoromethyl)-phenyl)borate, o-Tol = ortho-tolyl). © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：8274 / 8276
页数：3
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