Targeting Necroptosis as a Promising Therapy for Alzheimer's Disease

被引：15
|
作者：
Zhao, Wenli [1 ]
Liu, Yue [2 ]
Xu, Lijuan [1 ,2 ]
He, Yuan [3 ]
Cai, Zhenyu [1 ,3 ]
Yu, Jianqiang [1 ]
Zhang, Wannian [1 ,2 ]
Xing, Chengguo [4 ]
Zhuang, Chunlin [1 ,2 ]
Qu, Zhuo [1 ]
机构：
[1] Ningxia Med Univ, Sch Pharm, Yinchuan 750004, Ningxia, Peoples R China
[2] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
[3] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Canc Ctr, Shanghai 200070, Peoples R China
[4] Univ Florida, Dept Med Chem, Gainesville, FL 32610 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2022年 / 13卷 / 12期
基金：
中国国家自然科学基金; 国家重点研发计划; 中国科学院西部之光基金;
关键词：
Alzheimer's disease; necroptosis; RIPK1; RIPK3; MLKL; therapy; PROTEIN-KINASE; 1; TUMOR-NECROSIS-FACTOR; MIXED-LINEAGE KINASE; BLOOD-BRAIN-BARRIER; DOMAIN-LIKE PROTEIN; CELL-DEATH; RIP1; KINASE; MOLECULAR-MECHANISMS; NLRP3; INFLAMMASOME; O-GLCNACYLATION;
D O I：
10.1021/acschemneuro.2c00172
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder featured by memory loss and cognitive default. However, there has been no effective therapeutic approach to prevent the development of AD and the available therapies are only to alleviate some symptoms with limited efficacy and severe side effects. Necroptosis is a new kind of cell death, being regarded as a genetically programmed and regulated pattern of necrosis. Increasing evidence reveals that necroptosis is tightly related to the occurrence and development of AD. This review aims to summarize the potential role of necroptosis in AD progression and the therapeutic capacity of targeting necroptosis for AD patients.
引用
收藏
页码：1697 / 1713
页数：17
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