α-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei

被引：0
|
作者：
Braak, E
Sandmann-Keil, D
Rüb, U
Gai, WR
de Vos, RAI
Steur, ENHJ
Arai, K
Braak, H
机构：
[1] Univ Frankfurt, Dept Anat, D-60590 Frankfurt, Germany
[2] Flinders Univ S Australia, Med Ctr, Dept Physiol, Bedford Pk, SA 5042, Australia
[3] MST Hosp Grp, Dept Neurol, NL-7512 AD Enschede, Netherlands
[4] Lab Pathol Oost Nederland, NL-7512 AD Enschede, Netherlands
来源：
ACTA NEUROPATHOLOGICA | 2001年 / 101卷 / 03期
关键词：
Parkinson's disease; Lewy bodies; Lewy neurites; alpha-synuclein;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Advanced silver stains and immunohistochemical reactions against alpha -synuclein were used to detect Parkinson's disease-related cytoskeletal abnormalities in select lower brain stem nuclei. Various types of inclusion bodies including inconspicuous and heretofore unnoted granular particles and thread-like Lewy neurites were visualized. Of the nuclei investigated (gigantocellular reticular nucleus, bulbar raphe nuclei, coeruleus-subcoeruleus area), only lipofuscin- or neuromelanin-laden neuronal types showed a propensity to develop the pathological changes. Neuronal types devoid of pigment deposits remained free of the cytoskeletal abnormalities. Fine, dust-like particles and small globular Lewy bodies were encountered solely within the limits of intraneuronal lipofuscin or neuromelanin deposits.
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收藏
页码：195 / 201
页数：7
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