The neurobiology of APOE in schizophrenia and mood disorders

被引：20

作者：

Gibbons, Andrew Stuart ^{[1
,2
]}

Udawela, Madhara ^{[1
,3
]}

Jeon, Won Je ^{[1
]}

Seo, Myoung Suk ^{[1
,2
]}

Brooks, Lucy ^{[1
,4
,5
]}

Dean, Brian ^{[1
,2
,6
]}

机构：

[1] Mental Hlth Res Inst Victoria, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Psychiat, Parkville, Vic 3010, Australia

[3] Univ Melbourne, Ctr Neurosci, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Dept Anat & Cell Biol, Parkville, Vic 3010, Australia

[5] Univ Nottingham, Dept Neurosci, Nottingham NG7 2RD, England

[6] Monash Univ, Dept Psychol Med, Clayton, Vic 3800, Australia

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷

关键词：

Apoliprotein E; Schizophrenia; Bipolar Disorder; Depression; low density lipoprotein receptor; Review; DENSITY-LIPOPROTEIN RECEPTOR; HUMAN APOLIPOPROTEIN-E; MAJOR DEPRESSIVE DISORDER; CENTRAL-NERVOUS-SYSTEM; HETEROZYGOUS REELER MOUSE; E EPSILON-4 ALLELE; E MESSENGER-RNA; AGE-OF-ONSET; ALZHEIMERS-DISEASE; BIPOLAR DISORDER;

D O I：

10.2741/3729

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

APOE is a major component of several lipoproteins. In addition to its role as a lipid transport protein APOE also serves a dual role as a glial derived, synaptic signalling molecule and thought to play an important role in synaptic plasticity and cognition. Polymorphisms within the APOE gene have been associated with the incidence of Alzheimer's disease. In light of the similarities in the cognitive deficits experienced in both Alzheimer's disease and schizophrenia as well as the comorbidity of depression in Alzheimer's disease, aberrant APOE signalling has been implicated in the pathologies of schizophrenia and mood disorders. The schizophrenia candidate gene, reelin, also shares common receptors with APOE, further supporting a role for APOE in the pathology of these disorders. This review will summarise the current understanding of the involvement of APOE and its receptors in the symptomatology and pathology of schizophrenia and mood disorders and the implications of this involvement for drug treatment.

引用

页码：962 / 979

页数：18

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