precision medicine;
precision health;
genomics;
oral health and data analysis;
BIG DATA;
GENOMICS;
D O I:
10.1111/jphd.12315
中图分类号:
R78 [口腔科学];
学科分类号:
1003 ;
摘要:
Objectives The information in this article is based on a presentation given at the American Institute of Dental Public Health's 2018 Colloquium on Precision Public Health (PPH). A brief introduction to precision medicine provides context for PPH. Precision medicine tailors treatment and prevention strategies for individual patients based on variability of genetic, lifestyle, and environmental factors. An overview of PPH with examples of pilot studies with different research approaches bridges a discussion on an initiative undertaken by the University of Florida to build infrastructure and expertise for PPH research. Methods PPH use better and more precise data to target disease prevention and control in the right population at the right time. To facilitate the identification of relevant open access data sources for PPH research a "one-stop" shop was created and tested. Case studies were conducted to validate the data portal's usefulness in identifying at-risk populations. Results Details of portal data types, research challenges, and university-wide integrated programs are included. Case studies indicated that providing a "one-stop shop" of relevant data sources is an effective tool to aid researchers in identifying at-risk populations. Conclusions Research studies undertaken by University of Florida graduate students illustrate how PPH aligns with essential public health services including community engagement to reduce disparities in health care. Assurance of a competent workforce in PPH research approaches may be improved by training new researchers graduating from health science programs with knowledge of data and tools. The move toward PPH is in early stages and much work lies ahead.
机构:
Stanford Univ, Sch Med, Mol Imaging Program Stanford, Dept Radiol, Stanford, CA 94305 USA
Howard Hughes Med Inst, Chevy Chase, MD 20815 USAStanford Univ, Sch Med, Mol Imaging Program Stanford, Dept Radiol, Stanford, CA 94305 USA
Ge, T. Jessie
Vermesh, Ophir
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Mol Imaging Program Stanford, Dept Radiol, Stanford, CA 94305 USAStanford Univ, Sch Med, Mol Imaging Program Stanford, Dept Radiol, Stanford, CA 94305 USA
机构:
CDC, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA
NCI, Div Canc Control & Populat Sci, Rockville, MD USACDC, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA
Khoury, Muin J.
Iademarco, Michael F.
论文数: 0引用数: 0
h-index: 0
机构:
CDC, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA
US PHS, Commissioned Corps, Washington, DC 20201 USACDC, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA
Iademarco, Michael F.
Riley, William T.
论文数: 0引用数: 0
h-index: 0
机构:
NCI, Div Canc Control & Populat Sci, Rockville, MD USACDC, Ctr Surveillance Epidemiol & Lab Serv, Atlanta, GA 30333 USA
机构:
Govt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, AustraliaGovt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, Australia
Weeramanthri, Tarun Stephen
Dawkins, Hugh J. S.
论文数: 0引用数: 0
h-index: 0
机构:
Govt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, AustraliaGovt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, Australia
Dawkins, Hugh J. S.
Baynam, Gareth
论文数: 0引用数: 0
h-index: 0
机构:
Genet Serv Western Australia, Subiaco, WA, AustraliaGovt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, Australia
Baynam, Gareth
Bellgard, Matthew
论文数: 0引用数: 0
h-index: 0
机构:
Queensland Univ Technol, eRes Directorate, Brisbane, Qld, AustraliaGovt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, Australia
Bellgard, Matthew
Gudes, Ori
论文数: 0引用数: 0
h-index: 0
机构:
Univ New South Wales, Sydney, NSW, AustraliaGovt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, Australia
Gudes, Ori
Semmens, James Bernard
论文数: 0引用数: 0
h-index: 0
机构:
Curtin Univ, Perth, WA, AustraliaGovt Western Australia, Western Australian Dept Hlth, Publ & Aboriginal Hlth Div, Perth, WA, Australia