Substituent effects of the N,N-dimethyl-sulfamoyl group on the 1H and 13C NMR spectra of positional isomers of quinolines

The complete (1)H and (13)C NMR spectral assignments of seven positional isomers of N,N-dimethylsulfamoylquinolines 2-8 and quinoline have been made using 1D and 2D NMR techniques, including COSY, HMQC and HMBC experiments. Delta delta(H) and Delta delta(C) substituent effects induced by the sulfamoyl group were determined. The sulfamoyl substituent affects proton and carbon chemical shifts both in the parent and in the fused (pyridine or benzene) ring. Copyright (c) 2007 John Wiley & Sons, Ltd.