Simple and Efficient Preparation of 2,5-Disubstituted Oxazoles via a Metal-Free-Catalyzed Cascade Cyclization

被引：147
|
作者：
Wan, Changfeng
Gao, Linfeng
Wang, Qiang
Zhang, Jintang
Wang, Zhiyong [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Hefei 230026, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 17期
关键词：
SP(3) C-H; DIRECT ARYLATION; COPPER; INHIBITORS; OXIDATION;
D O I：
10.1021/ol101596s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical and simple synthesis of 2,5-disubstituted oxazoles was developed via an iodine-catalyzed tandem oxidative cyclization. A wide range of common commercial aromatic aldehydes can be used as reaction substrates, which displayed excellent functional group compatibility in this reaction.
引用
收藏
页码：3902 / 3905
页数：4
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