Highly Enantioselective and Anti-Diastereoselective Catalytic Intermolecular Glyoxylate-Ene Reactions: Effect of the Geometrical Isomers of Alkenes

被引：12

作者：

Zhang, Xiang ^{[1
]}

Wang, Min ^{[1
]}

Ding, Ran ^{[1
]}

Xu, Yun-He ^{[1
]}

Loh, Teck-Peng ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 11期

关键词：

ALPHA-HYDROXY ESTERS; DICATIONIC PALLADIUM(II) COMPLEXES; BASE CHROMIUM(III) COMPLEXES; HIGH ENANTIOMERIC PURITIES; CHIRAL LEWIS-ACIDS; CARBONYL-ENE; ASYMMETRIC CATALYSIS; STEREOSELECTIVE-SYNTHESIS; IN(III)-PYBOX COMPLEX; COPPER(II) COMPLEXES;

D O I：

10.1021/acs.orglett.5b01151

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of homoallylic alcohols with high enantioselectivities and anti-diastereoselectivities via an In(III)-catalyzed intermolecular glyoxylateene reaction has been developed. The geometrical isomers of alkenes were shown to have different reactivities. Only the isomers of the alkenes having a proton beta-cis to the substituent reacted in this catalytic system.

引用

页码：2736 / 2739

页数：4