Upregulation of long noncoding RNA MALAT1 in papillary thyroid cancer and its diagnostic value

被引：22
|
作者：
Liu, Jia [1 ]
Dong, Hanhua [2 ]
Yang, Yingxu [2 ]
Qian, Yuejun [2 ]
Liu, Jianqiu [3 ,4 ,5 ]
Li, Zhi [3 ,4 ,5 ]
Guan, Hongya [1 ]
Chen, Zheng [2 ]
Li, Cuilin [3 ,4 ,5 ]
Zhang, Ke [3 ,4 ,5 ]
Zhang, Qingsong [2 ]
Cao, Wei [1 ]
Lv, Jing [2 ]
机构：
[1] Zhengzhou Univ, Zhengzhou Cent Hosp, Translat Med Ctr, Zhengzhou 450007, Henan, Peoples R China
[2] Zhengzhou Univ, Zhengzhou Cent Hosp, Thyroid Surg, Zhengzhou 450007, Henan, Peoples R China
[3] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
[4] Cent S Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China
[5] Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 29期
关键词：
diagnostic; long noncoding RNAs; MALAT1; papillary thyroid cancer; LYMPH-NODE METASTASES; COMPUTED-TOMOGRAPHY; EXPRESSION; CARCINOMA; PROLIFERATION; ASSOCIATION; RECURRENCE; MIGRATION; INVASION; PATTERN;
D O I：
10.2217/fon-2018-0416
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To investigate the expression level of lncRNA MALAT1 in papillary thyroid cancer (PTC) and evaluate its clinical diagnostic value as a biomarker in PTC. Methods:MALAT1 lncRNA expression in tissues was detected by qRT-PCR. The diagnostic value of MALAT1 as a biomarker in PTC was evaluated with receiver operating characteristics. Results:MALAT1 expression was upregulated in PTC tissues compared with paired corresponding noncancerous tissues. We also found that upregulated MALAT1 expression was correlated with tumor size, lymph node metastases (p =0.011) and WHO disease stage. The area under the curve was 0.6320, 0.7192, 0.7089 and 0.7000 for PTC, lymph node metastasis, extrathyroidal extension and WHO disease stage prediction, respectively. Conclusion: Our finding suggests that MALAT1 may exert oncogenic function in PTC and may be a potential diagnostic marker for this cancer.
引用
收藏
页码：3015 / 3022
页数：8
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