Classical swine H1N1 influenza viruses confer cross protection from swine-origin 2009 pandemic H1N1 influenza virus infection in mice and ferrets

被引：22
|
作者：
Min, Ji-Young [1 ]
Chen, Grace L. [1 ]
Santos, Celia [1 ]
Lamirande, Elaine W. [1 ]
Matsuoka, Yumiko [1 ]
Subbarao, Kanta [1 ]
机构：
[1] NIAID, LID, NIH, Bethesda, MD 20892 USA
来源：
VIROLOGY | 2010年 / 408卷 / 01期
关键词：
2009 pandemic influenza; Classical swine H1N1 influenza; Cross-protection; JANUARY-FEBRUARY; 1976; NEW-JERSEY; FORT-DIX; TRANSMISSION; HUMANS; VACCINE; PATHOGENESIS; EVOLUTION; OUTBREAK;
D O I：
10.1016/j.virol.2010.09.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The hemagglutinin of the 2009 pandemic H1N1 influenza virus is a derivative of and is antigenically related to classical swine but not to seasonal human H1N1 viruses. We compared the A/California/7/2009 (CA/7/09) virus recommended by the WHO as the reference virus for vaccine development, with two classical swine influenza viruses A/swine/Iowa/31 (sw/IA/31) and A/New Jersey/8/1976 (NJ/76) to establish the extent of immunologic cross-reactivity and cross-protection in animal models. Primary infection with 2009 pandemic or NJ/76 viruses elicited antibodies against the CA/7/09 virus and provided complete protection from challenge with this virus in ferrets: the response in mice was variable and conferred partial protection. Although ferrets infected with sw/IA/31 virus developed low titers of cross-neutralizing antibody, they were protected from pulmonary replication of the CA/7/09 virus. The data suggest that prior exposure to antigenically related H1N1 viruses of swine-origin provide some protective immunity against the 2009 pandemic H1N1 virus. Published by Elsevier Inc.
引用
收藏
页码：128 / 133
页数：6
相关论文
共 50 条
  • [1] Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice
    Maines, Taronna R.
    Jayaraman, Akila
    Belser, Jessica A.
    Wadford, Debra A.
    Pappas, Claudia
    Zeng, Hui
    Gustin, Kortney M.
    Pearce, Melissa B.
    Viswanathan, Karthik
    Shriver, Zachary H.
    Raman, Rahul
    Cox, Nancy J.
    Sasisekharan, Ram
    Katz, Jacqueline M.
    Tumpey, Terrence M.
    [J]. SCIENCE, 2009, 325 (5939) : 484 - 487
  • [2] Protection of Ferrets from Infection by Swine-Origin 2009 A (H1N1) Influenza Virus by the Inactivated Vaccine
    Shin, Jin Soo
    Do Hwang, Seon
    Kim, Hyun Soo
    Cho, Sung Whan
    Seo, Sang Heui
    [J]. VIRAL IMMUNOLOGY, 2010, 23 (04) : 395 - 402
  • [3] The novel influenza A/H1N1 or (2009) Influenza A/H1N1 or "Swine-origin influenza A (H1N1)"
    Cabezas Fernandez del Campo, Jose Antonio
    [J]. ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA, 2009, 75 (04): : 947 - 963
  • [4] Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets
    Munster, Vincent J.
    de Wit, Emmie
    van den Brand, Judith M. A.
    Herfst, Sander
    Schrauwen, Eefje J. A.
    Bestebroer, Theo M.
    van de Vijver, David
    Boucher, Charles A.
    Koopmans, Marion
    Rimmelzwaan, Guus F.
    Kuiken, Thijs
    Osterhaus, Albert D. M. E.
    Fouchier, Ron A. M.
    [J]. SCIENCE, 2009, 325 (5939) : 481 - 483
  • [5] Novel Swine-Origin Influenza A: The 2009 H1N1 Influenza Virus
    Abdel-Haq, Nahed M.
    Asmar, Basim I.
    [J]. INDIAN JOURNAL OF PEDIATRICS, 2011, 78 (01): : 74 - 80
  • [6] Immunity to Pre-1950 H1N1 Influenza Viruses Confers Cross-Protection against the Pandemic Swine-Origin 2009 A (H1N1) Influenza Virus
    Skountzou, Ioanna
    Koutsonanos, Dimitrios G.
    Kim, Jin Hyang
    Powers, Ryan
    Satyabhama, Lakshmipriyadarshini
    Masseoud, Feda
    Weldon, William C.
    Martin, Maria del Pilar
    Mittler, Robert S.
    Compans, Richard
    Jacob, Joshy
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 185 (03): : 1642 - 1649
  • [7] The 2009 Swine-Origin Influenza A (H1N1) Epidemic
    Wood, Beverly P.
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 2010, 194 (02) : 294 - 295
  • [8] Emergence of a Novel Swine-Origin Influenza A (H1N1) Virus in Humans Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team
    Dawood, Fatimah S.
    Jain, Seema
    Finelli, Lyn
    Shaw, Michael W.
    Lindstrom, Stephen
    Garten, Rebecca J.
    Gubareva, Larisa V.
    Xu, Xiyan
    Bridges, Carolyn B.
    Uyeki, Timothy M.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (25): : 2605 - 2615
  • [9] Swine-origin Influenza A (H1N1) Virus Pandemic: Is it a Sprint or a Marathon?
    Behbehani, Nasser
    [J]. KUWAIT MEDICAL JOURNAL, 2009, 41 (03): : 185 - 186
  • [10] Emergence and pandemic potential of swine-origin H1N1 influenza virus
    Gabriele Neumann
    Takeshi Noda
    Yoshihiro Kawaoka
    [J]. Nature, 2009, 459 : 931 - 939
12345