Prognostic Potential of N-Cadherin in Oral Squamous Cell Carcinoma via Immunohistochemical Methods

被引：1
|
作者：
Chandolia, Betina [1 ]
Rajliwal, Jai Parkash [2 ]
Bajpai, Manas [1 ]
Arora, Manika [1 ]
机构：
[1] NIMS Dent Coll, Dept Oral Pathol, Jaipur 302001, Rajasthan, India
[2] PGIMS, Dept Prevent & Community Med, Med Rd, Rohtak, Haryana, India
来源：
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN | 2017年 / 27卷 / 08期
关键词：
N-cadherin; Oral epithelial dysplasia; Oral squamous cell carcinoma; MESENCHYMAL TRANSITION; CANCER-CELLS; EXPRESSION; ADHESION; INVASION; BREAST; PROGRESSION; METASTASIS; MARKER;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To assess the prognostic potential for N-cadherin in oral squamous cell carcinoma and oral epithelial dysplasia. Study Design: A cross-sectional study, analytical study. Place and Duration of Study: Maharishi Markandeshwar College of Dental Science Research (MMCDSR), Ambala, India, from 2011 to 2014. Methodology: Immunohistochemistry was used to observe the N-cadher in expression in 100 cases having epithelium with normal oral mucosa, oral epithelial dysplastic lesions and oral squamous cell carcinoma (OSCC). For statistical significance, SPSS 13.0 was used to calculate the data by Mann-Whitney and Kruskal-Wallis tests. Results: In OSCC, N-cadherin expression was more evident than in oral epithelial dysplasia followed by the normal oral epithelium that did not show any dysplastic changes (p=0.001). Conversely, N-cadherin expression was not significant among the histological grade of OSCC. Conclusion: N-cadherin can be used as a potential biomarker for early diagnosis of OSCC. However, the N-cadherin expression did not show any correlation with the histological grade of OSCC.
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收藏
页码：475 / 478
页数：4
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