Blockade of rat chemokine receptor CCR1 by BX471 is able to reverse chronic allograft nephropathy

被引:0
|
作者
Bedke, J
Kiss, E
Horuk, R
Nelson, P
Gröne, HJ
机构
来源
JOURNAL OF UROLOGY | 2005年 / 173卷 / 04期
关键词
D O I
10.1016/S0022-5347(18)35679-9
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
1545
引用
收藏
页码:418 / 418
页数:1
相关论文
共 25 条
  • [1] Effects of blocking chemokine receptor CCR1 with BX471 in two models of fibrosis prevention and rescue in mice
    Weber, Susanne N.
    Nowak, Irina
    Gruenhage, Frank
    Lammert, Frank
    BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2021, 27
  • [2] Therapeutic Effect of C-C Chemokine Receptor Type 1 (CCR1) Antagonist BX471 on Allergic Rhinitis
    Feng, Suoyi
    Ju, Longzhu
    Shao, Ziqi
    Grzanna, Mark
    Jia, Lu
    Liu, Ming
    JOURNAL OF INFLAMMATION RESEARCH, 2020, 13 : 343 - 356
  • [3] BX471: A CCR1 antagonist with anti-inflammatory activity in man
    Horuk, R
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (09) : 791 - 804
  • [4] Predictions of CCR1 chemokine receptor structure and BX 471 antagonist binding followed by experimental validation
    Vaidehi, Nagarajan
    Schlyer, Sabine
    Trabanino, Rene J.
    Floriano, Wely B.
    Abrol, Ravinder
    Sharma, Shantanu
    Kochanny, Monica
    Koovakat, Sunil
    Dunning, Laura
    Liang, Meina
    Fox, James M.
    Lopes de Mendonca, Filipa
    Pease, James E.
    Goddard, William A., III
    Horuk, Richard
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (37) : 27613 - 27620
  • [5] Protective role of BX471, a non-peptide CCR1 antagonist, in acute pancreatitis and sepsis
    He, M.
    Horuk, R.
    Bhatia, M.
    FEBS JOURNAL, 2006, 273 : 286 - 286
  • [6] Cross-species pharmacokinetics and allometric scaling of the CCR1 antagonists: BX471 and CP-481,715
    Riska, Paul
    Nagaraja, Raj
    Gan, Lawrence
    Spero, Denice
    DRUG METABOLISM REVIEWS, 2006, 38 : 217 - 217
  • [7] CCR1 blockade prevents progression of chronic allograft nephropathy by inhibition of the fibrogenic activity of macrophages
    Bedke, J.
    Kiss, E.
    Schaefer, L.
    Behnes, C.-L.
    Bonrouhi, M.
    Gretz, N.
    Horuk, R.
    Nelson, P. J.
    Groene, H.-J.
    PATHOLOGY RESEARCH AND PRACTICE, 2007, 203 (05) : 286 - 287
  • [8] Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival
    Hantrah, Pedram
    Yamagami, Satoru
    Liu, Ying
    Zhang, Qiang
    Vora, Sudhir S.
    Lu, Bao
    Gerard, Craig J.
    Dana, M. Reza
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (03) : 1228 - 1236
  • [9] Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection
    Gao, W
    Topham, PS
    King, JA
    Smiley, ST
    Csizmadia, V
    Lu, B
    Gerard, CJ
    Hancock, WW
    JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (01): : 35 - 44
  • [10] Treatment with BX471, a CC chemokine receptor 1 antagonist, attenuates systemic inflammatory response during sepsis
    He, Min
    Horuk, Richard
    Moochhala, Shabbir M.
    Bhatia, Madhav
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 292 (04): : G1173 - G1180