Genetic influence alters the brain synchronism in perception and timing

被引:13
|
作者
Marinho, Victor [1 ,2 ,3 ]
Oliveira, Thomaz [1 ,2 ]
Bandeira, Juliete [1 ]
Pinto, Giovanny R. [2 ,3 ]
Gomes, Anderson [2 ]
Lima, Valeria [2 ]
Magalhaes, Francisco [1 ,3 ]
Rocha, Kaline [1 ,3 ]
Ayres, Carla [1 ]
Carvalho, Valecia [1 ,3 ]
Velasques, Bruna [4 ]
Ribeiro, Pedro [4 ]
Orsini, Marco [5 ]
Bastos, Victor Hugo [6 ]
Gupta, Daya [7 ]
Teixeira, Silmar [1 ,3 ]
机构
[1] Univ Fed Piaui, Neuroinnovat Technol & Brain Mapping Lab, Av Sao Sebastiao 2819, BR-64202020 Parnaiba, PI, Brazil
[2] Univ Fed Piaui, Genet & Mol Biol Lab, Parnaiba, Brazil
[3] Univ Fed Piaui, Northeast Biotechnol Network RENORBIO, Teresina, Brazil
[4] Univ Fed Rio de Janeiro, Brain Mapping & Sensory Motor Integrat Lab, Rio De Janeiro, Brazil
[5] Univ Ctr Augusto Motta UNISUAM, Masters Program Local Dev & Hlth Sci Appl Program, Rio De Janeiro, Brazil
[6] Univ Fed Piaui, Brain Mapping & Funct Lab, Parnaiba, Brazil
[7] Camden Cty Coll, Dept Biol, Blackwood, NJ USA
关键词
Time perception; Genetic polymorphisms; Serotonin; Dopamine; Circadian rhythm; GABA; TIME PERCEPTION; WORKING-MEMORY; CIRCADIAN MODULATION; ALLELIC VARIATION; LINKAGE ANALYSIS; POLYMORPHISMS; ASSOCIATION; DISORDER; GABA; RECEPTORS;
D O I
10.1186/s12929-018-0463-z
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Background: Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception. Main Text: This study suggests that the polymorphisms genetic SLC6A4 5-HTTLPR, 5HTR2A T102C, DRD2/ANKK1-Taq1A, SLC6A3 3'-UTR VNTR, COMT Val158Met, CLOCK genes and GABRB2 A/C as modification factor at neurochemical levels associated with several neurofunctional aspects, modifying the circadian rhythm and built-in cognitive functions in the timing. We conducted a literature review with 102 studies that met inclusion criteria to synthesize findings on genetic polymorphisms and their influence on the timing. Conclusion: The findings suggest an association of genetic polymorphisms on behavioral aspects related in timing. However, order to confirm the paradigm of association in the timing as a function of the molecular level, still need to be addressed future research.
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页数:11
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