Role of cardiac dyssynchrony and resynchronization therapy in functional mitral regurgitation

被引：49

作者：

Spartera, Marco ^{[1
]}

Galderisi, Maurizio ^{[2
]}

Mele, Donato ^{[3
]}

Cameli, Matteo ^{[4
]}

D'Andrea, Antonello ^{[5
]}

Rossi, Andrea ^{[6
]}

Mondillo, Sergio ^{[4
]}

Novo, Giuseppina ^{[7
]}

Esposito, Roberta ^{[2
]}

D'Ascenzi, Flavio ^{[4
]}

Montisci, Roberta ^{[8
]}

Gallina, Sabina ^{[9
]}

Margonato, Alberto ^{[1
]}

Agricola, Eustachio ^{[1
]}

机构：

[1] Hosp San Raffaele, IRCCS, Cardiovasc Dept, Div Cardiol, Via Olgettina 60, I-20132 Milan, Italy

[2] Federico II Univ Hosp, Dept Adv Biomed Sci, Naples, Italy

[3] Univ Ferrara, Dept Cardiol, I-44100 Ferrara, Italy

[4] Univ Siena, Dept Cardiovasc Dis, Via Laterina 8, I-53100 Siena, Italy

[5] Univ Naples 2, dei Colli Monaldi Hosp, Dept Cardiol, Naples, Italy

[6] Univ Verona, Cardiol Sect, Dept Med, I-37100 Verona, Italy

[7] Univ Hosp Paolo Giaccone, Dept Cardiol, Palermo, Italy

[8] Univ Cagliari, Clin Cardiol, Cagliari, Italy

[9] Univ G DAnnunzio, Div Cardiol, S Camillo de Lellis Hosp, Chieti, Italy

来源：

EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING | 2016年 / 17卷 / 05期

关键词：

cardiac resynchronization; mitral regurgitation; ventricular dyssynchrony; IDIOPATHIC DILATED CARDIOMYOPATHY; HEART-FAILURE; VENTRICULAR DYSSYNCHRONY; STRESS ECHOCARDIOGRAPHY; MECHANISM; REDUCTION; MORTALITY; EXERCISE; INSIGHTS; IMPACT;

D O I：

10.1093/ehjci/jev352

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Functional mitral regurgitation (FMR) is a common complication of left ventricle (LV) dysfunction and remodelling. Recently, it has been recognized as an independent prognostic factor in both ischaemic and non-ischaemic LV dysfunctions. In this review article, we discuss the mechanisms through which cardiac dyssynchrony is involved in FMR pathophysiologic cascade and how cardiac resynchronization therapy (CRT) can have therapeutic effects on FMR by reverting specific dyssynchrony pathways. We analyse recent clinical trials focusing on CRT impact on FMR in 'real-world' patients, the limits and future perspectives that could eventually generate new predictors of CRT response in terms of FMR reduction. Finally, we propose a practical diagnostic and therapeutic strategy for the management of symptomatic patients with severe LV dysfunction and concomitant 'prognostic' FMR.

引用

页码：471 / 480

页数：10

共 50 条

[1] The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation
Russo, Eleonora
Russo, Giulio
Cassese, Mauro
Braccio, Maurizio
Carella, Massimo
Compagnucci, Paolo
Dello Russo, Antonio
Casella, Michela
[J]. CELLS, 2022, 11 (15)
[2] Changes in functional mitral regurgitation after cardiac resynchronization therapy
Marsan, Nina Ajmone
Bax, Jeroen J.
[J]. EUROPEAN HEART JOURNAL, 2010, 31 (19) : 2323 - 2325
[3] Functional mitral regurgitation and reverse remodelling in cardiac resynchronization therapy
Cabrera-Bueno, F.
Garcia-Pinilla, J. M.
Pena-Hernandez, J.
Jimenez-Navarro, M.
Gomez-Doblas, J. J.
Barrera-Cordero, A.
Alzueta-Rodriguez, J.
de Teresa-Galvan, E.
[J]. JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2007, 18 : S46 - S46
[4] Cardiac Resynchronization Therapy and Mitral Regurgitation
Solis, J.
Handschumacher, M.
Levine, R.
Hung, J.
[J]. CARDIOLOGY, 2007, 107 (04) : 454 - 454
[5] Mitral Regurgitation and Cardiac Resynchronization Therapy
Vinereanu, Dragos
[J]. ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, 2008, 25 (10): : 1155 - 1166
[6] Papillary muscle dyssynchrony mediated functional mitral regurgitation: mechanistic insights and modulation by cardiac resynchronization
Bartko, P.
Arfsten, H.
Heitzinger, G.
Pavo, N.
Strunk, G.
Gwechenberger, M.
Hengstenberg, C.
Binder, T.
Huelsmann, M.
Goliasch, G.
[J]. WIENER KLINISCHE WOCHENSCHRIFT, 2018, 130 : 23 - 24
[7] Resynchronization of the papillary muscles with cardiac resynchronization therapy results in reduction of functional mitral regurgitation
Ypenburg, Claudia
Lancellotti, Patrizio
Bleeker, Gabe B.
Tops, Laurens F.
Holman, Eduard R.
Schalij, Martin J.
Van der Wall, Ernst E.
Pierard, Luc A.
Bax, Jeroen J.
[J]. CIRCULATION, 2007, 116 (16) : 627 - 627
[8] Effect of cardiac resynchronization therapy on functional mitral regurgitation in heart failure
Lancellotti, P
Mélon, P
Sakalihasan, N
Waleffe, A
Dubois, C
Bertholet, M
Piérard, LA
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 2004, 94 (11): : 1462 - 1465
[9] Functional mitral regurgitation and ventricular arrhythmias in patients with cardiac resynchronization therapy
Yoshimura, A.
Suzuki, A.
Yoshida, A.
Kanai, M.
Hasegawa, S.
Kataoka, S.
Yazaki, K.
Saito, C.
Yagishita, D.
Domoto, S.
Shiga, T.
Ashihara, K.
Shoda, M.
Niinami, H.
Yamaguchi, J.
[J]. EUROPEAN HEART JOURNAL, 2023, 44
[10] FUNCTIONAL MITRAL REGURGITATION AND CARDIAC RESYNCHRONIZATION THERAPY: EVOLUTION AND IMPACT ON OUTCOME
van der Bijl, Pieter
Khidir, Mand
Marsan, Nina
Delgado, Victoria
Bax, Jeroen
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 69 (11) : 695 - 695

← 1 2 3 4 5 →