Inhaled aprotinin reduces viral load in mild-to-moderate inpatients with SARS-CoV-2 infection

被引:2
|
作者
Redondo-Calvo, Francisco Javier [1 ,2 ,3 ]
Padin, Juan Fernando [2 ,3 ]
Martinez-Alarcon, Jose [4 ]
Munoz-Rodriguez, Jose Ramon [2 ,3 ]
Serrano-Oviedo, Leticia [2 ]
Lopez-Juarez, Pilar [2 ]
Porras Leal, Maria Lourdes [5 ]
Gonzalez Gasca, Francisco Javier [3 ,5 ]
Rodriguez Martinez, Marta [6 ]
Perez Serrano, Raul [6 ]
Sanchez Cadena, Abraham [6 ]
Bejarano-Ramirez, Natalia [3 ,7 ]
Munoz Hornero, Constanza [8 ]
Villegas Fernandez-Infantes, Maria Dolores [5 ]
Manrique Romo, Maria Isabel [5 ]
Gomez-Romero, Francisco Javier [2 ,3 ]
Perez-Ortiz, Jose Manuel [2 ,3 ]
机构
[1] Univ Gen Hosp, Dept Anesthesiol & Crit Care Med, Ciudad Real, Spain
[2] Univ Gen Hosp Ciudad Real, Translat Res Unit, C Obispo Rafael Torija S-N, Ciudad Real 13005, Spain
[3] Univ Castilla La Mancha, Sch Med Ciudad Real, Dept Med Sci, Ciudad Real, Spain
[4] Univ Gen Hosp Ciudad Real, Dept Microbiol, Ciudad Real, Spain
[5] Univ Gen Hosp Ciudad Real, Dept Internal Med, Ciudad Real, Spain
[6] Univ Gen Hosp Ciudad Real, Dept Pharm, Ciudad Real, Spain
[7] Univ Gen Hosp Ciudad Real, Dept Paediat, Ciudad Real, Spain
[8] Gen Hosp Puertollano, Dept Internal Med, Puertollano, Spain
关键词
D O I
10.1111/eci.13850
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页数:5
相关论文
共 50 条
  • [1] Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection
    Vermillion, Meghan S.
    Murakami, Eisuke
    Ma, Bin
    Pitts, Jared
    Tomkinson, Adrian
    Rautiola, Davin
    Babusis, Darius
    Irshad, Hammad
    Seigel, Dustin
    Kim, Cynthia
    Zhao, Xiaofeng
    Niu, Congrong
    Yang, Jesse
    Gigliotti, Andrew
    Kadrichu, Nani
    Bilello, John P.
    Ellis, Scott
    Bannister, Roy
    Subramanian, Raju
    Smith, Bill
    Mackman, Richard L.
    Lee, William A.
    Kuehl, Philip J.
    Hartke, Jim
    Cihlar, Tomas
    Porter, Danielle P.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2022, 14 (633)
  • [2] Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
    Chansavath Phetsouphanh
    David R. Darley
    Daniel B. Wilson
    Annett Howe
    C. Mee Ling Munier
    Sheila K. Patel
    Jennifer A. Juno
    Louise M. Burrell
    Stephen J. Kent
    Gregory J. Dore
    Anthony D. Kelleher
    Gail V. Matthews
    [J]. Nature Immunology, 2022, 23 : 210 - 216
  • [3] Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
    Phetsouphanh, Chansavath
    Darley, David
    Wilson, Daniel B.
    Howe, Annett
    Munier, C. Mee Ling
    Patel, Sheila K.
    Juno, Jennifer A.
    Burrell, Louise M.
    Kent, Stephen J.
    Dore, Gregory J.
    Kelleher, Anthony D.
    Matthews, Gail, V
    [J]. NATURE IMMUNOLOGY, 2022, 23 (02) : 210 - +
  • [4] Regdanvimab in patients with mild-to-moderate SARS-CoV-2 infection: A propensity score-matched retrospective cohort study
    Lee, Shinwon
    Lee, Soon Ok
    Lee, Jeong Eun
    Kim, Kye-Hyung
    Lee, Sun Hee
    Hwang, Soyoon
    Kim, Shin-Woo
    Chang, Hyun-Ha
    Kim, Yoonjung
    Bae, Sohyun
    Kim, A-Sol
    Kwon, Ki Tae
    [J]. INTERNATIONAL IMMUNOPHARMACOLOGY, 2022, 106
  • [5] SARS-CoV-2 viral RNA levels are not 'viral load'
    Michalakis, Yannis
    Sofonea, Mircea T.
    Alizon, Samuel
    Bravo, Ignacio G.
    [J]. TRENDS IN MICROBIOLOGY, 2021, 29 (11) : 970 - 972
  • [6] Infection of SARS-CoV-2 in domestic dogs associated with owner viral load
    de Souza Barbosa, Altina Bruna
    Kmetiuk, Louise Bach
    de Carvalho, Otavio Valerio
    Drulla Brandao, Ana Perola
    Doline, Fernando Rodrigo
    Rangel Silveira Lopes, Sibele Rejane
    Meira, Douglas Adamoski
    de Souza, Emanuel Maltempi
    Trindade, Edvaldo da Silva
    Baura, Valter
    Barbosa, David Soeiro
    Brandespim, Daniel Friguglietti
    Galhardo, Juliana Arena
    Pettan-Brewer, Christina
    de Sa Guimaraes, Ana Marcia
    Dutra, Valeria
    de Morais, Helio Autran
    Huergo, Luciano
    dos Santos, Andrea Pires
    Biondo, Alexander Welker
    [J]. RESEARCH IN VETERINARY SCIENCE, 2022, 153 : 61 - 65
  • [7] SARS-CoV-2 detection, viral load and infectivity over the course of an infection
    Walsh, Kieran A.
    Jordan, Karen
    Clyne, Barbara
    Rohde, Daniela
    Drummond, Linda
    Byrne, Paula
    Ahern, Susan
    Carty, Paul G.
    O'Brien, Kirsty K.
    O'Murchu, Eamon
    O'Neill, Michelle
    Smith, Susan M.
    Ryan, Mairin
    Harrington, Patricia
    [J]. JOURNAL OF INFECTION, 2020, 81 (03) : 357 - 371
  • [8] Surgical Outcomes in Cancer Patients Undergoing Elective Surgery After Recovering from Mild-to-Moderate SARS-CoV-2 Infection
    Kothari, Anai N.
    DiBrito, Sandra R.
    Lee, J. Jack
    Caudle, Abigail S.
    Clemens, Mark W.
    Gottumukkala, Vijaya N.
    Katz, Matthew H. G.
    Offodile, Anaeze C.
    Uppal, Abhineet
    Chang, George J.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2021, 28 (13) : 8046 - 8053
  • [9] SARS-CoV-2 Omicron infection is associated with high nasopharyngeal viral load
    Salvagno, Gian Luca
    Henry, Brandon M.
    Pighi, Laura
    De Nitto, Simone
    Montagnana, Martina
    Lippi, Giuseppe
    [J]. JOURNAL OF INFECTION, 2022, 84 (06) : 868 - 870
  • [10] Surgical Outcomes in Cancer Patients Undergoing Elective Surgery After Recovering from Mild-to-Moderate SARS-CoV-2 Infection
    Anai N. Kothari
    Sandra R. DiBrito
    J. Jack Lee
    Abigail S. Caudle
    Mark W. Clemens
    Vijaya N. Gottumukkala
    Matthew H. G. Katz
    Anaeze C. Offodile
    Abhineet Uppal
    George J. Chang
    [J]. Annals of Surgical Oncology, 2021, 28 : 8046 - 8053