Osmium(VI) complexes as a new class of potential anti-cancer agents

被引：44
|
作者：
Ni, Wen-Xiu [1 ]
Man, Wai-Lun [1 ]
Cheung, Myra Ting-Wai [1 ]
Sun, Raymond Wai-Yin [2 ,3 ]
Shu, Yuan-Lan [4 ]
Lam, Yun-Wah [1 ]
Che, Chi-Ming [2 ,3 ]
Lau, Tai-Chu [1 ]
机构：
[1] City Univ Hong Kong, Dept Biol & Chem, Kowloon Tong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
[3] Univ Hong Kong, Open Lab Chem Biol, Inst Mol Technol Drug Discovery & Synth, Hong Kong, Hong Kong, Peoples R China
[4] State Key Lab Incubat Base Chinese Med & Mol Phar, Shenzhen, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 07期
关键词：
METAL-COMPLEXES; INORGANIC-CHEMISTRY; RUTHENIUM; CANCER; CHEMOTHERAPY; REACTIVITY; BIOLOGY;
D O I：
10.1039/c0cc04515b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A nitridoosmium(VI) complex [Os-VI(N)(sap)(OH2)Cl] (H(2)sap = N-salicylidene-2-aminophenol) displays prominent in vitro and in vivo anti-cancer properties, induces S-and G2/M-phase arrest and forms a stable adduct with dianionic 5'-guanosine monophosphate.
引用
收藏
页码：2140 / 2142
页数：3
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