Cannabinoid effects in basal ganglia in a rat model of Parkinson's disease

被引：58
|
作者：
Sañudo-Peña, MC
Patrick, SL
Khen, S
Patrick, RL
Tsou, K
Walker, JM
机构：
[1] Brown Univ, Dept Psychol, Schrier Res Lab, Providence, RI 02912 USA
[2] Brown Univ, Dept Neurosci, Providence, RI 02912 USA
来源：
NEUROSCIENCE LETTERS | 1998年 / 248卷 / 03期
关键词：
cannabinoids; circling; substantia nigra; globus pallidus; striatum; 6-hydroxydopamine;
D O I：
10.1016/S0304-3940(98)00368-1
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Cannabinoid receptors in the brain are highly concentrated in the basal ganglia, which is in accordance with their well known effects on motor behavior. In this study, rats with 6-hydroxydopamine lesions of the nigrostriatal pathway were implanted with cannulae in the striatum, globus pallidus and substantia nigra. The effect of unilateral infusion of the potent cannabinoid agonist CP55,940 on turning behavior was studied for each structure. Lesioned animals responded to intrapallidal and intrastriatal administration of the cannabinoid in a manner that was similar to that of unlesioned animals. However, lesioned animals showed greater contralateral turning in response to the cannabinoid infusions in the substantia nigra than unlesioned animals. (C) 1998 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：171 / 174
页数：4
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