Modeling Pancreatic Cancer through Somatic Editing with AAV

被引：0

作者：

Curiel-Garcia, Alvaro ^{[1
]}

Olive, Kenneth P. ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Herbert Irving Comprehens Canc Ctr, Dept Med, New York, NY 10032 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2019年 / 25卷 / 05期

关键词：

DELIVERY; CRISPR/CAS9;

D O I：

10.1016/j.molmed.2019.02.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetically engineered mouse models have revolutionized the study of pancreatic cancer, but have several technical and practical limitations. A new adenoassociated virus (AAV)-driven somatic genome-editing model of pancreatic ductal adenocarcinoma reported by Ideno et al. (Lab. Invest. published online February 6, 2019; https://doi.org/10.1038/s41374-018-0171-z) addresses several of these limitations, achieving rapid and penetrant induction of multiple targeted alterations in the adult murine pancreas.

引用

页码：361 / 362

页数：2

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