Progress in liquid chromatography-mass spectrometry instrumentation and its impact on high-throughput screening

被引：129
|
作者：
Niessen, WMA
机构：
[1] Hyphen Mass Spec Consultancy, NL-2332 XT Leiden, Netherlands
[2] Fac Sci, Dept Analyt Chem & Appl Spect, NL-1081 HV Amsterdam, Netherlands
来源：
JOURNAL OF CHROMATOGRAPHY A | 2003年 / 1000卷 / 1-2期
关键词：
reviews; instrumentation; LC-MS; liquid chromatography-mass spectrometry; interfaces; ionization techniques; mass analysis; high-throughput screening;
D O I：
10.1016/S0021-9673(03)00506-5
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
In the past 10 years, liquid chromatography-mass spectrometry (LC-MS) has rapidly matured to become a very powerful and useful analytical tool that is widely applied in many areas of chemistry, pharmaceutical sciences and biochemistry. In this paper, recent instrumental developments in LC-MS-related interfacing, ionization and mass analysis are reviewed from the perspective of the application of LC-MS in high-throughput screening of combinatorial libraries and the related high-throughput quantitative bioanalysis in early drug-discovery studies, such as early adsorption, distribution, metabolism and excretion studies. (C) 2003 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：413 / 436
页数：24
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