Preparation of fast response superabsorbent hydrogels by radiation polymerization and crosslinking of N-isopropylacrylamide in solution

被引：33
|
作者：
El-Mohdy, H. L. Abd [2 ]
Safrany, Agnes [1 ]
机构：
[1] Hungarian Acad Sci, Inst Isotopes, H-1525 Budapest, Hungary
[2] Natl Ctr Radiat Res & Technol, Nasr, Cairo, Egypt
来源：
RADIATION PHYSICS AND CHEMISTRY | 2008年 / 77卷 / 03期
关键词：
hydrogel; absorbent; temperature responsiveness; radiation polymerization; drug release;
D O I：
10.1016/j.radphyschem.2007.05.006
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Macroporous temperature-responsive poly(N-isopropyl acrylamide) (PNIPAAm) hydrogels with high equilibrium swelling and fast response rates were obtained by a Co-60 gamma- and electron beam (EB) irradiation of aqueous N-isopropylacrylamide (NIPAAm) monomer solutions. The effect of irradiation temperatures, the dose, the addition of a pore-forming agent on the swelling ratio, and the kinetics of swelling and shrinking of the PNIPAArn gels was studied. The gels synthesized above the LCST exhibited the highest equilibrium swelling (300-400) and fastest response rate measured by minutes. Scanning electron microscope (SEM) pictures revealed that the gels synthesized above the LCST have larger pores than those prepared at temperatures below the LCST. The gels showed a reversible response to cyclical changes in temperature and might be used in a pulsed drug delivery device. The gels synthesized above the LCST exhibited the highest testosterone propionate release. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：273 / 279
页数：7
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