Animal model for study of human hepatitis viruses

被引：40
|
作者：
Chayama, Kazuaki [1 ,2 ]
Hayes, C. Nelson [2 ]
Hiraga, Nobuhiko [2 ]
Abe, Hiromi [2 ]
Tsuge, Masataka [2 ]
Imamura, Michio [2 ]
机构：
[1] Hiroshima Univ, Dept Med & Mol Sci, Div Frontier Med Sci, Programs Biomed Res,Grad Sch Biomed Sci,Minami Ku, Hiroshima 7348551, Japan
[2] Liver Res Project Ctr, Hiroshima, Japan
来源：
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2011年 / 26卷 / 01期
关键词：
hepatitis B virus; hepatitis C virus; uPA; scid mouse model; HEPATOCYTE CHIMERIC MOUSE; UPA-SCID MOUSE; C-VIRUS; B-VIRUS; IN-VIVO; HUMAN LIVER; TRANSGENIC MICE; ANTIVIRAL ACTIVITY; HCV REPLICATION; HBV INFECTION;
D O I：
10.1111/j.1440-1746.2010.06470.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Human hepatitis B virus (HBV) and hepatitis C virus (HCV) infect only chimpanzees and humans. Analysis of both viruses has long been hampered by the absence of a small animal model. The recent development of human hepatocyte chimeric mice has enabled us to carry out studies on viral replication and cellular changes induced by replication of human hepatitis viruses. Various therapeutic agents have also been tested using this model. In the present review, we summarize published studies using chimeric mice and discuss the merits and shortcomings of this model.
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收藏
页码：13 / 18
页数：6
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