Briaviolide Q, a New Briarane from the Cultured Briareum violaceum

被引：0

作者：

Tsai, Tsung-Chang ^{[1
]}

Xu, Jing-Hao ^{[2
,3
]}

Li, Mu-Jang ^{[1
]}

Chen, Jih-Jung ^{[4
]}

Su, Jui-Hsin ^{[2
,3
]}

Wu, Yang-Chang ^{[5
,6
,7
,8
]}

Wen, Zhi-Hong ^{[9
]}

Sung, Ping-Jyun ^{[2
,3
,5
,8
,9
]}

机构：

[1] Antai Tian Sheng Mem Hosp, Antai Med Care Corp, Pingtung 928, Taiwan

[2] Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 944, Taiwan

[3] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[4] Natl Yang Ming Univ, Fac Pharm, Taipei 112, Taiwan

[5] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[6] Kaohsiung Med Univ, Res Ctr Nat Prod & Drug Dev, Kaohsiung 807, Taiwan

[7] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan

[8] China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 404, Taiwan

[9] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 10期

关键词：

Briareum violaceum; Briaviolide; Briarane; iNOS; DITERPENES; OCTOCORAL;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new briarane-type diterpenoid, briaviolide Q (1), along with a known analogue, excavatolide Z (2), were obtained from a cultured octocoral Briareum violaceum. Details of the isolation and structure determination of briarane 1 from spectroscopic data arc presented in this paper. In RAW264.7 cells, a macrophage-like murine cell line, briarane 1 was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in cells stimulated by lipopolysaccharide (LPS).

引用

页码：1235 / 1237

页数：3

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