The role of single nucleotide polymorphisms in breast cancer metastasis

被引：7
|
作者：
Rae, James M. [1 ]
Skaar, Todd C. [2 ]
Hilsenbeck, Susan G. [3 ]
Oesterreich, Steffi [3 ]
机构：
[1] Univ Michigan, Med Ctr, Dept Internal Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA
[2] Indiana Univ, Sch Med, Div Clin Pharmacol, Indianapolis, IN 46202 USA
[3] Baylor Coll Med, Breast Ctr, Dept Med & Mol & Cellular Biol, Houston, TX 77030 USA
来源：
BREAST CANCER RESEARCH | 2008年 / 10卷 / 01期
关键词：
D O I：
10.1186/bcr1842
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Our understanding of many aspects of cancer biology has been advanced through the use of modern genetics. These studies have already shown that germ line polymorphisms play a significant role in disease initiation and response to therapy. However, what is less well studied is the role of germ line polymorphisms in cancer progression. Studies in rodents indicate that differential susceptibility to cancer metastasis can be heritable; thus, the search for the genes that control cancer metastasis is underway. Although some provocative studies suggest potential candidates for metastasis regulating genes, the conclusive identification of a specific inherited genetic variant that alters metastatic potential awaits further studies.
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页数：2
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