Effect of Acyclovir on HIV-1 Set Point among Herpes Simplex Virus Type 2-Seropositive Persons during Early HIV-1 Infection

被引：9

作者：

Kim, H. Nina ^{[1
,4
]}

Wang, Jing ^{[7
]}

Hughes, James ^{[7
]}

Coombs, Robert ^{[2
,4
,5
]}

Sanchez, Jorge ^{[11
]}

Reid, Stewart ^{[8
,12
]}

Delany-Moretlwe, Sinead ^{[13
]}

Cowan, Frances ^{[14
]}

Fuchs, Jonathan ^{[9
,11
]}

Eshleman, Susan H. ^{[10
]}

Khaki, Leila ^{[7
]}

McMahon, Moira A. ^{[10
]}

Siliciano, Robert F. ^{[10
]}

Wald, Anna ^{[4
,7
]}

Celum, Connie ^{[3
,4
,6
]}

机构：

[1] Univ Washington, Harborview Med Ctr, Sch Med, Dept Med, Seattle, WA 98104 USA

[2] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98104 USA

[3] Univ Washington, Sch Med, Dept Global Hlth, Seattle, WA 98104 USA

[4] Univ Washington, Sch Publ Hlth, Dept Med, Seattle, WA 98104 USA

[5] Univ Washington, Sch Publ Hlth, Dept Lab Med, Seattle, WA 98104 USA

[6] Univ Washington, Sch Publ Hlth, Dept Global Hlth, Seattle, WA 98104 USA

[7] Fred Hutchinson Canc Res Ctr, Stat Ctr HIV AIDS Res & Prevent, Seattle, WA 98104 USA

[8] Univ Alabama, Dept Med, Birmingham, AL 35294 USA

[9] San Francisco Dept Publ Hlth, San Francisco, CA USA

[10] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[11] Asociac Civil Impacta Salud & Educ IMPACTA, Lima, Peru

[12] Ctr Infect Dis Res Zambia, Lusaka, Zambia

[13] Univ Witwatersrand, Reprod Hlth Unit, Johannesburg, South Africa

[14] UCL, London, England

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷 / 05期

基金：

美国国家卫生研究院;

关键词：

REVERSE-TRANSCRIPTASE; SEROCONVERSION; ACQUISITION; RESISTANCE; MUTATION; COHORT; UGANDA; TRIAL; RAKAI; MEN;

D O I：

10.1086/655662

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse-transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons (HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (Pp. 30) or CD4 cell counts (Pp. 85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point.

引用

页码：734 / 738

页数：5

共 50 条

[1] Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection
Cachay, Edward R.
Frost, Simon D. W.
Richman, Douglas D.
Smith, Davey M.
Little, Susan J.
JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (09): : 1270 - 1277
[2] Herpes Simplex Virus Type 2 Suppressive Therapy with Acyclovir or Valacyclovir Does Not Select for Specific HIV-1 Resistance in HIV-1/HSV-2 Dually Infected Persons
Baeten, Jared M.
Lingappa, Jairam
Beck, Ingrid
Frenkel, Lisa M.
Pepper, Gregory
Celum, Connie
Wald, Anna
Fife, Kenneth H.
Were, Edwin
Mugo, Nelly
Sanchez, Jorge
Essex, Myron
Makhema, Joseph
Kiarie, James
Farquhar, Carey
Corey, Lawrence
JOURNAL OF INFECTIOUS DISEASES, 2011, 203 (01): : 117 - 121
[3] Herpes simplex virus type 2 seroprevalence and incidence in acute and chronic HIV-1 infection
Lagnese, M.
Daar, E. S.
Christenson, P.
Rieg, G.
INTERNATIONAL JOURNAL OF STD & AIDS, 2011, 22 (08) : 463 - 464
[4] In vitro reactivation of HIV-1 by stimulation with herpes simplex virus infection
Moriuchi, M
Moriuchi, H
SEXUALLY TRANSMITTED DISEASES, 2002, 29 (05) : 308 - 309
[5] Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2
Celum, C.
Wald, A.
Lingappa, J. R.
Magaret, A. S.
Wang, R. S.
Mugo, N.
Mujugira, A.
Baeten, J. M.
Mullins, J. I.
Hughes, J. P.
Bukusi, E. A.
Cohen, C. R.
Katabira, E.
Ronald, A.
Kiarie, J.
Farquhar, C.
Stewart, G. J.
Makhema, J.
Essex, M.
Were, E.
Fife, K. H.
de Bruyn, G.
Gray, G. E.
McIntyre, J. A.
Manongi, R.
Kapiga, S.
Coetzee, D.
Allen, S.
Inambao, M.
Kayitenkore, K.
Karita, E.
Kanweka, W.
Delany, S.
Rees, H.
Vwalika, B.
Stevens, W.
Campbell, M. S.
Thomas, K. K.
Coombs, R. W.
Morrow, R.
Whittington, W. L. H.
McElrath, M. J.
Barnes, L.
Ridzon, R.
Corey, L.
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 362 (05): : 427 - 439
[6] A prospective study of genital herpes simplex virus type 2 infection in human immunodeficiency virus type 1 (HIV-1)-seropositive women: Correlations with CD4 cell count and plasma HIV-1 RNA level
Wright, PW
Hoesley, CJ
Squires, KE
Croom-Rivers, A
Weiss, HL
Gnann, JW
CLINICAL INFECTIOUS DISEASES, 2003, 36 (02) : 207 - 211
[7] Roles of clinical and subclinical reactivated herpes simplex virus type 2 infection and human immunodeficiency virus type 1 (HIV-1)-induced immunosuppression on genital and plasma HIV-1 levels
Nagot, N.
Ouedraogo, A.
Konate, I.
Weiss, H. A.
Foulongne, V.
Defer, M. C.
Sanon, A.
Becquart, P.
Segondy, M.
Sawadogo, A.
Van de Perre, P.
Mayaud, P.
JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (02): : 241 - 249
[8] Human immunodeficiency virus (HIV) antibody avidity testing to identify recent infection in newly diagnosed HIV type 1 (HIV-1)-seropositive persons infected with diverse HIV-1 subtypes
Chawla, A.
Murphy, G.
Donnelly, C.
Booth, C. L.
Johnson, M.
Parry, J. V.
PhillipS, A.
Geretti, A. M.
JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (02) : 415 - 420
[9] Herpes simplex virus type 2 (HSV-2) seroprevalence at the time of HIV-1 diagnosis and seroincidence after HIV-1 diagnosis in an ethnically diverse cohort of HIV-1-infected persons
Ramaswamy, M
Sabin, C
McDonald, C
Smith, M
Taylor, C
Geretti, AM
SEXUALLY TRANSMITTED DISEASES, 2006, 33 (02) : 96 - 101
[10] Impact of HIV-1 Infection on Herpes Simplex Virus Type 2 Genetic Variability Among Co-Infected Individuals
Abrao, Emiliana P.
Burrel, Sonia
Desire, Nathalie
Bonnafous, Pascale
Godet, Angelique
Caumes, Eric
Agut, Henri
Boutolleau, David
JOURNAL OF MEDICAL VIROLOGY, 2015, 87 (03) : 357 - 365

← 1 2 3 4 5 →