Activity of the TGF-beta 2 specific antisense oligodeoxynucleotide trabedersen in an orthotopic xenograft mouse model of metastatic pancreatic cancer

被引:0
|
作者
Jaschinski, F. [1 ]
Lang, S. A. [2 ]
Moser, C. [2 ]
Schlitt, H. J. [2 ]
Schneider, A. [1 ]
Schlingensiepen, K. H. [1 ]
机构
[1] Antisense Pharma, Preclin Res & Dev, Regenburg, Germany
[2] Univ Med Ctr Regensburg, Dept Surg, Regenburg, Germany
来源
EJC SUPPLEMENTS | 2010年 / 8卷 / 07期
关键词
D O I
10.1016/S1359-6349(10)72237-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:169 / 169
页数:1
相关论文
共 50 条
  • [1] Effect of the TGF-beta 2 specific antisense oligodeoxynucleotide trabedersen on TGF-beta 2 and -beta 1 expression in human glioma cells: Cross-regulatory loops regulate TGF-beta isoform expression
    Jaschinski, F.
    Kielmanowicz, M.
    Rothhammer, T.
    Schneider, A.
    Schlingensiepen, K. H.
    EJC SUPPLEMENTS, 2010, 8 (07): : 113 - 114
  • [2] Targeted suppression of TGF-beta2 by trabedersen (AP 12009) in an orthotopic xenograft melanoma mouse model
    Rothhammer-Hampl, Tanja
    Jaschinski, Frank
    Baeuerlein, Veronika
    Haarstrich, Carina
    Heinrichs, Hubert
    Schneider, Anneliese
    CANCER RESEARCH, 2012, 72
  • [3] INHIBITION OF TGF-BETA(3) (BUT NOT TGF-BETA(1) OR TGF-BETA(2)) ACTIVITY PREVENTS NORMAL MOUSE EMBRYONIC PALATE FUSION
    BRUNET, CL
    SHARPE, PM
    FERGUSON, MWJ
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 1995, 39 (02): : 345 - 355
  • [4] Antitumor Activity of Intratumoral Ethanol Injection in an Orthotopic Pancreatic Cancer Cell Mouse Xenograft Model
    Zhang, Wen-Ying
    Jin, Zhen-Dong
    Liu, Feng
    Yuan, Hai-Hua
    Jiang, Bin
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2018, 2018
  • [5] TGF-beta2 antisense oligonucleotide AP 12009 (trabedersen) as a therapeutic agent in colorectal cancer
    Jaschinski, Frank
    Rothhammer, Tanja
    Fischer, Dagmar
    Kick, Carola
    Kielmanowicz, Marcus
    Jachimczak, Piotr
    Schlingensiepen, Karl-Hermann
    CANCER RESEARCH, 2009, 69
  • [6] TGF-beta promotes angiogenesis in an RB-deficient, Kras-driven mouse model of pancreatic cancer
    Gore, Jesse
    Craven, Kelly E.
    Wilson, Julie L.
    Korc, Murray
    CANCER RESEARCH, 2015, 75
  • [7] Antimetastatic activity of ISTH0047, a potent and selective TGF-beta 2 antisense oligonucleotide, in syngeneic lung metastatic model of mouse 4T1 mammary carcinoma
    Wosikowski, Katja
    Hasenbach, Kathy
    Petschenka, Jutta
    Roldan, Diana Barea
    Kreiter, Sebastian
    Sahin, Ugur
    Serin, Guillaume
    Redon, Julie-Orlane
    de Boisferon, Marc Hillairet
    Bichat, Francis
    Kohonen, Hanna
    Janicot, Michel
    CANCER RESEARCH, 2016, 76
  • [8] Transforming growth factor-beta (TGF-β) inhibitor modulates cancer stroma in a pancreatic cancer orthotopic mouse model
    Murakami, Takashi
    Hiroshima, Yukihiko
    Miyake, Kentaro
    Kiyuna, Tasuku
    Hwang, Ho Kyoung
    Kawaguchi, Kei
    DeLong, Jonathan C.
    Lwin, Thinzer M.
    Igarashi, Kentaro
    Matsuyama, Ryusei
    Mori, Ryutaro
    Kumamoto, Takafumi
    Chishima, Takashi
    Tanaka, Kuniya
    Bouvet, Michael
    Endo, Itaru
    Hoffman, Robert M.
    CANCER RESEARCH, 2017, 77
  • [9] Effect of 2G8, a TGF-beta-R2 inhibitor, on TGF-beta signaling and migration in an immunocompetent pancreatic cancer model.
    Ostapoff, Katherine
    Cenik, Bercin
    Schwarz, Roderich
    Brekken, Rolf A.
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (04)
  • [10] A mouse model for in vivo detection and disruption of TGF-beta signaling in breast cancer bone metastasis
    Kang, Y.
    Korpal, M.
    Yan, J.
    Lu, X.
    CLINICAL & EXPERIMENTAL METASTASIS, 2008, 25 : 26 - 26