The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation

被引:25
|
作者
Ludewig, Peter [1 ]
Winneberger, Jack [1 ]
Magnus, Tim [1 ]
机构
[1] Univ Med Ctr Hamburg Eppendorf, Dept Neurol, Martinistr 52, D-20246 Hamburg, Germany
关键词
BLOOD-BRAIN-BARRIER; LEUKOCYTE TRANSENDOTHELIAL MIGRATION; CHOROID-PLEXUS; IN-VITRO; ADHERENS JUNCTIONS; NEUROVASCULAR UNIT; ISCHEMIC-STROKE; TIGHT JUNCTIONS; VE-CADHERIN; MOUSE MODEL;
D O I
10.1016/j.jneuroim.2018.10.012
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e.g., stroke or ischemia-reperfusion injury) the endothelial functions are impaired, leading to increased vascular permeability, vascular inflammation, leukocyte-endothelium interactions, and transendothelial migration, driving CNS inflammation and neuronal destruction. This review describes the current knowledge on the regulatory roles of endothelial cells in neuroinflammatory processes.
引用
收藏
页码:38 / 44
页数:7
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