Synthesis, Structure, and Antifungal Activities of 3-(Difluoromethyl)-Pyrazole-4-Carboxylic Oxime Ester Derivatives

被引：5
|
作者：
Wang, Bin [1 ,3 ]
Chen, Wei-Ting [1 ,3 ]
Min, Li-Jing [2 ]
Han, Liang [1 ]
Sun, Na-Bo [3 ]
Liu, Xing-Hai [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang P, Huzhou 313000, Zhejiang, Peoples R China
[3] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China
来源：
HETEROATOM CHEMISTRY | 2022年 / 2022卷
关键词：
NEMATOCIDAL ACTIVITY; CRYSTAL-STRUCTURE; DESIGN; DOCKING;
D O I：
10.1155/2022/6078017
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fifteen new pyrazole-4-carboxylic oxime ester derivatives were conveniently synthesized, and their structures were confirmed by H-1 NMR, C-13 NMR, HRMS, and X-ray diffraction. Antifungal assays indicated that some of these compounds possessed good activity against S. sclerotiorum, B. cinerea, R. solani, P. oryae, and P. piricola at 50 ppm. Structure-activity relationships (SAR) were studied by molecular docking simulation.
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页数：8
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