Over the past 20 years, stem cell technologies have become an increasingly attractive option to investigate and treat neurodegenerative diseases. In the current review, we discuss the process of extending basic stem cell research into translational therapies for patients suffering from neurodegenerative diseases. We begin with a discussion of the burden of these diseases on society, emphasizing the need for increased attention toward advancing stem cell therapies. We then explain the various types of stem cells utilized in neurodegenerative disease research, and outline important issues to consider in the transition of stem cell therapy from bench to bedside. Finally, we detail the current progress regarding the applications of stem cell therapies to specific neurodegenerative diseases, focusing on Parkinson disease, Huntington disease, Alzheimer disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. With a greater understanding of the capacity of stem cell technologies, there is growing public hope that stem cell therapies will continue to progress into realistic and efficacious treatments for neurodegenerative diseases. ANN NEUROL 2011;70:353-361
机构:
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
De Gioia, Roberta
Biella, Fabio
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Univ Milan, Dept Pathophysiol & Transplantat DEPT, Dino Ferrari Ctr, Neurosci Sect, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Biella, Fabio
Citterio, Gaia
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Univ Milan, Dept Pathophysiol & Transplantat DEPT, Dino Ferrari Ctr, Neurosci Sect, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Citterio, Gaia
Rizzo, Federica
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Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Pathophysiol & Transplantat DEPT, Dino Ferrari Ctr, Neurosci Sect, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Rizzo, Federica
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Abati, Elena
Nizzardo, Monica
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Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Pathophysiol & Transplantat DEPT, Dino Ferrari Ctr, Neurosci Sect, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Nizzardo, Monica
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Bresolin, Nereo
Comi, Giacomo Pietro
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Univ Milan, Dept Pathophysiol & Transplantat DEPT, Dino Ferrari Ctr, Neurosci Sect, I-20122 Milan, Italy
Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neuromuscular & Rare Dis Unit, Via Francesco Sforza 35, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Comi, Giacomo Pietro
Corti, Stefania
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Fdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
Univ Milan, Dept Pathophysiol & Transplantat DEPT, Dino Ferrari Ctr, Neurosci Sect, I-20122 Milan, ItalyFdn IRCCS Ca Granda Osped Maggiore Policlin, Neurol Unit, Via Francesco Sforza 35, I-20122 Milan, Italy
机构:
Genzyme Corp, Ctr Sci, Framingham, MA 01701 USAGenzyme Corp, Ctr Sci, Framingham, MA 01701 USA
Shihabuddin, Lamya S.
Aubert, Isabelle
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Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A1, CanadaGenzyme Corp, Ctr Sci, Framingham, MA 01701 USA
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Oakland Univ, Dept Biol Sci, Rochester, MI 48309 USA
Oakland Univ, Dept Fdn Med Studies, William Beaumont Sch Med, Rochester, MI 48309 USAOakland Univ, Dept Biol Sci, Rochester, MI 48309 USA
Sivandzade, Farzane
Cucullo, Luca
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Oakland Univ, Dept Fdn Med Studies, William Beaumont Sch Med, Rochester, MI 48309 USAOakland Univ, Dept Biol Sci, Rochester, MI 48309 USA
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VA Almazov Fed Ctr Heart Blood & Endocrinol, Res Unit Cellular & Genet Engn, Akkuratova St 2, St Petersburg 197341, Russia
Russian Acad Sci, Inst Cytol, Dept Intracellular Signaling & Transport, St Petersburg, RussiaVA Almazov Fed Ctr Heart Blood & Endocrinol, Res Unit Cellular & Genet Engn, Akkuratova St 2, St Petersburg 197341, Russia