Stem Cell Technology for Neurodegenerative Diseases

被引:177
|
作者
Lunn, J. Simon [1 ]
Sakowski, Stacey A. [1 ]
Hur, Junguk [1 ]
Feldman, Eva L. [1 ]
机构
[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
关键词
AMYOTROPHIC-LATERAL-SCLEROSIS; FACTOR GENE-THERAPY; RAT MODEL; GROWTH-FACTOR; SPINAL-CORD; SUBTHALAMIC NUCLEUS; NEUROTROPHIC FACTOR; PARKINSON-DISEASE; DOPAMINE NEURONS; MOUSE MODEL;
D O I
10.1002/ana.22487
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Over the past 20 years, stem cell technologies have become an increasingly attractive option to investigate and treat neurodegenerative diseases. In the current review, we discuss the process of extending basic stem cell research into translational therapies for patients suffering from neurodegenerative diseases. We begin with a discussion of the burden of these diseases on society, emphasizing the need for increased attention toward advancing stem cell therapies. We then explain the various types of stem cells utilized in neurodegenerative disease research, and outline important issues to consider in the transition of stem cell therapy from bench to bedside. Finally, we detail the current progress regarding the applications of stem cell therapies to specific neurodegenerative diseases, focusing on Parkinson disease, Huntington disease, Alzheimer disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. With a greater understanding of the capacity of stem cell technologies, there is growing public hope that stem cell therapies will continue to progress into realistic and efficacious treatments for neurodegenerative diseases. ANN NEUROL 2011;70:353-361
引用
收藏
页码:353 / 361
页数:9
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