Self-assembled structures having a regular hollow icosahedral form (such as those observed for proteins of virus capsids) can occur as a result of biomineralization processes(1), but are extremely rare in mineral crystallites(2). Compact icosahedra made from a boron oxide have been reported(3), but equivalent structures made of synthetic organic components such as surfactants have not hitherto been observed. It is, however, well known that lipids, as well as mixtures of anionic and cationic single chain surfactants, can readily form bilayers(4,5) that can adopt a variety of distinct geometric forms: they can fold into soft vesicles or random bilayers (the so-called sponge phase) or form ordered stacks of flat or undulating membranes(6). Here we show that in salt-free mixtures of anionic and cationic surfactants, such bilayers can self-assemble into hollow aggregates with a regular icosahedral shape. These aggregates are stabilized by the presence of pores located at the vertices of the icosahedra. The resulting structures have a size of about one micrometre and mass of about 10(10) daltons, making them larger than any known icosahedral protein assembly(7) or virus capsid(8). We expect the combination of wall rigidity and holes at vertices of these icosahedral aggregates to be of practical value for controlled drug or DNA release.
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China Univ Petr East China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R ChinaChina Univ Petr East China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China
Wang, Dong
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Cao, Yueying
Sun, Yawei
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China Univ Petr East China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R ChinaChina Univ Petr East China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China
Sun, Yawei
Wang, Jiqian
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China Univ Petr East China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R ChinaChina Univ Petr East China, State Key Lab Heavy Oil Proc, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China