Role of MMP-1, MMP-8 and MMP-9 gene polymorphisms in preterm birth

被引：9
|
作者：
Pandey, Monika [1 ]
Awasthi, Shally [1 ]
机构：
[1] King Georges Med Univ, Dept Pediat, Lucknow 226 003, Uttar Pradesh, India
来源：
JOURNAL OF GENETICS | 2019年 / 99卷 / 01期
关键词：
infection; inflammation; matrix metalloproteinases; polymorphism; preterm birth; PREMATURE RUPTURE; MATRIX; RISK; MEMBRANES; PROMOTER; METALLOPROTEINASES;
D O I：
10.1007/s12041-019-1161-7
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Novel approaches to preterm births are underway building upon our prior discoveries and probing into unknown discovery pathways. The recent findings showed a high affinity of MMP-9 in serum and its polymorphisms for preterm birth. This study, which is a hospital-based case-control study, aims to investigate the association of MMP-1, MMP-8 and MMP-9 polymorphisms, and levels of MMP-9 in preterm birth. Increased level of MMP-9 was reported in cases as compared to control. The significant association of MMP-9 (-1562) CT (P = 0.001; OR = 1.44 (CI = 0.97-2.14)) and TT genotype (P = 0.05; OR = 2.6 (CI = 1.46-4.69)) were reported in preterm birth. Our findings suggest that the MMP-9 plays an important role in contributing preterm labour and this can be used as a diagnostic tool during pregnancy.
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页数：7
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