The single nucleotide polymorphism (SNP) in DNA repair genes by homologous recombination (XRCC2 and RAD51) and the risk of sporadic breast cancer in Poland

被引：0
|
作者：
Romanowicz, Hanna [1 ]
Smolarz, Beata [1 ]
Baszczynski, Jakub [2 ]
Zadrozny, Marek [2 ]
Kulig, Andrzej [1 ]
Goralczyk, Bozena
Polac, Ireneusz [3 ]
Pertynski, Tomasz [3 ]
机构：
[1] Inst Ctr Zdrowia Matki Polki, Zaklad Patomorfol Klin, Pracownia Biol Mol, PL-93338 Lodz, Poland
[2] Inst Ctr Zdrowia Matki Polki, Klin Chirurg Onkologicznej & Chorob Piersi, PL-93338 Lodz, Poland
[3] Inst Ctr Zdrowia Matki Polki, Klin Ginekol & Chorob Menopauzy, PL-93338 Lodz, Poland
来源：
PRZEGLAD MENOPAUZALNY | 2011年 / 10卷 / 01期
关键词：
XRCC2; RAD51; breast cancer; gene polymorphism; MUTATION CARRIERS; 5'-UNTRANSLATED REGION; MAMMALIAN-CELLS; SUSCEPTIBILITY;
D O I：
暂无
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background: Single nucleotide polymorphisms in the DNA repair genes have been extensively studied in association with various human cancers such as breast cancer. Material and methods: We investigated an association of polymorphisms in the DNA repair genes XRCC2-Arg188His and RAD51-135G/C with the breast cancer risk. Genotypes were analysed by PCR-RFLP assays in 80 patients with breast cancer and 80 controls. Results: The distribution of the genotypes of XRCC2 Arg188His in both controls and patients did not differ significantly (p > 0,05) from those predicted by the Hardy-Weinberg distribution. The C/C genotype of RAD51 increased the risk of breast cancer occurrence (OR 2.29; 95% PU (0.91-5.72), p = 0.04). Conclusion: G135C polymorphism of the RAD51 gene may be associated with the incidence of sporadic breast cancer in Polish women.
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页码：10 / 14
页数：5
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