Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study

被引：260
|
作者：
Yamout, Bassem [5 ]
Hourani, Roula [1 ]
Salti, Haytham [2 ]
Barada, Wissam [5 ]
El-Hajj, Taghrid [5 ]
Al-Kutoubi, Aghiad [1 ]
Herlopian, Aline [5 ]
Baz, Elizabeth Kfoury [3 ]
Mahfouz, Rami [3 ]
Khalil-Hamdan, Rima [3 ]
Kreidieh, Nabeela M. A. [3 ]
El-Sabban, Marwan [4 ]
Bazarbachi, Ali [5 ]
机构：
[1] Amer Univ Beirut Med Ctr, Dept Radiol, Beirut, Lebanon
[2] Amer Univ Beirut Med Ctr, Dept Ophthalmol, Beirut, Lebanon
[3] Amer Univ Beirut Med Ctr, Dept Pathol & Lab Med, Beirut, Lebanon
[4] Amer Univ Beirut Med Ctr, Dept Human Morphol, Beirut, Lebanon
[5] Amer Univ Beirut Med Ctr, Dept Internal Med, Beirut, Lebanon
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 227卷 / 1-2期
关键词：
Mesenchymal stem cells; Autologous; Intrathecal; Multiple sclerosis; Magnetic resonance imaging; Optical coherence tomography; Expanded disability status scale; PROGENITOR CELLS; IMMUNE-RESPONSE; POTENTIAL USE; ENCEPHALOMYELITIS; INJECTION; CHILDREN; REPAIR;
D O I：
10.1016/j.jneuroim.2010.07.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3,6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events. (c) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：185 / 189
页数：5
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