Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory

被引：220
|
作者：
Murray, Andrew J. [1 ]
Sauer, Jonas-Frederic [1 ]
Riedel, Gernot [1 ]
McClure, Christina [1 ]
Ansel, Laura [1 ]
Cheyne, Lesley [1 ]
Bartos, Marlene [1 ]
Wisden, William [1 ]
Wulff, Peer [1 ]
机构：
[1] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland
来源：
NATURE NEUROSCIENCE | 2011年 / 14卷 / 03期
基金：
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
HIPPOCAMPAL; SCHIZOPHRENIA; INHIBITION; BEHAVIOR; NEURONS;
D O I：
10.1038/nn.2751
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
引用
收藏
页码：297 / 299
页数：3
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