TNFR2 mediated TNF-α signaling and NF-κB activation in hippocampus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice

被引:7
|
作者
Ghosh, Nabanita [1 ]
Mitra, Soham [1 ]
Sinha, Priyobrata [2 ]
Chakrabarti, Nilkanta [2 ]
Bhattacharyya, Arindam [1 ]
机构
[1] Univ Calcutta, Dept Zool, Immunol Lab, 35 Ballygunge Circular Rd, Kolkata 700019, India
[2] Univ Calcutta, Dept Physiol, 92 Acharya Prafulla Chandra Rd, Kolkata 700009, India
关键词
Hippocampus; MPTP; TNF-alpha; TNFR2; p65/p52; COPPER-INDUCED IMMUNOTOXICITY; PROMOTE NEUROINFLAMMATION; P50/P65; HETERODIMER; MOUSE MODEL; RECEPTORS; APOPTOSIS; ESTROGEN; PATHWAY; GDNF; NEUROTOXICITY;
D O I
10.1016/j.neures.2018.02.007
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) -induced neuroinflammation and its impact in hippocampus remain elusive till date. Our present study includes the time dependent changes of inflammatory molecules in mouse hippocampus during MPTP treatment. MPTP treatment increased level of TNF-alpha, enhanced expression of TNFR2 along with PI3 kinase (PI3K) induced phosphorylation of Akt resulting in persistent nuclear factor-kappa B (NF-kappa B) activation. The expressions gradually increased from Dayl post-MPTP treatment, maximally at Day3 post-treatment. MPTP induced translocation of p65 and p52, two subunits of NF-kappa B family, to nucleus where they had been found to dimerize. Therefore, MPTP induced TINF-alpha signaling through TNFR2 mediated pathway and recruited p65-p52 dimer in hippocampal nucleus which is reported to have protective effect on hippocampal neurons indicated by unchanged neuronal count in hippocampus in treated groups with respect to control. Our finding suggests that this unique NF-kappa B dimer plays some role in providing inherent protection to hippocampus during MPTP-treatment. (C) 2018 Published by Elsevier B.V.
引用
收藏
页码:36 / 42
页数:7
相关论文
共 50 条
  • [1] Apoptosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice
    Fukudo, T
    Takahashi, J
    Xiang, F
    Tanaka, J
    [J]. BRAIN PATHOLOGY, 2000, 10 (04) : 787 - 787
  • [2] MOTOR FUNCTION IN THE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED MOUSE
    DONNAN, GA
    WILLIS, GL
    KACZMARCZYK, SJ
    ROWE, P
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1987, 77 (2-3) : 185 - 191
  • [3] Neuronal cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.
    Fukuda, T
    Takahashi, J
    Tanaka, J
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2000, 59 (05): : 462 - 462
  • [4] SPINAL-CORD METABOLISM OF THE 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-TREATED MONKEY
    SCHWARTZMAN, RJ
    ALEXANDER, GM
    [J]. BRAIN RESEARCH, 1985, 337 (02) : 263 - 268
  • [5] An appraisal of the antiparkinsonian activity of piribedil in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets
    Smith, L
    DeSalvia, M
    Jenner, P
    Marsden, CD
    [J]. MOVEMENT DISORDERS, 1996, 11 (02) : 125 - 135
  • [6] Neuronal cell death in 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine-treated mice
    Fukuda, T
    Takahashi, J
    Xiang, FG
    Tanaka, J
    [J]. FRONTIERS OF THE MECHANISMS OF MEMORY AND DEMENTIA, 2000, (1200): : 79 - 82
  • [7] Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice
    Turmel, H
    Hartmann, A
    Parain, K
    Douhou, A
    Srinivasan, A
    Agid, Y
    Hirsch, EC
    [J]. MOVEMENT DISORDERS, 2001, 16 (02) : 185 - 189
  • [8] Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated adult mice
    Yamada, M
    Onodera, M
    Mizuno, Y
    Mochizuki, H
    [J]. NEUROSCIENCE, 2004, 124 (01) : 173 - 181
  • [9] Effects of riluzole on the electrophysiological activity of pallidal neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey
    Boraud, T
    Bezard, E
    Stutzmann, JM
    Bioulac, B
    Gross, CE
    [J]. NEUROSCIENCE LETTERS, 2000, 281 (2-3) : 75 - 78
  • [10] Pallidal border cells: An anatomical and electrophysiological study in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkey
    Bezard, E
    Boraud, T
    Chalon, S
    Brotchie, JM
    Guilloteau, D
    Gross, CE
    [J]. NEUROSCIENCE, 2001, 103 (01) : 117 - 123