Singlet oxygen - is it useful for PDT?

被引：0

作者：

Kogan, BY ^{[1
]}

Butenin, AV ^{[1
]}

机构：

[1] Organ Intermediates & Dyes Inst, Moscow 103787, Russia

来源：

CLINICAL LASERS AND DIAGNOSTICS | 2000年 / 4156卷

关键词：

PDT; singlet oxygen; oxygen consumption;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Oxygen is the limited component in PDT, especially in the hypoxic tissues. Proteins and amino acids are the main oxidation substrates in tissues in the case of singlet oxygen while, for example, hydroxy radicals well oxidize also DNA and membrane lipids which are considered as the critical targets in PDT. We compared the quantum yields of the oxygen consumption by Type I and by Type II mechanisms in the aqueous solutions in the comparable with PDT conditions. The preparation Photosens was used as photosensitizer, human albumin serum - as oxidation substrate, and sodium ascorbate - as reductant. We conclude that the oxygen consumption proceeds mainly by Type Il mechanism while PDT efficiency by Type I mechanism can be even higher.

引用

页码：91 / 95

页数：5

共 50 条

[1] Comparison of singlet oxygen threshold dose for PDT
Zhu, Timothy C.
Liu, Baochang
Kim, Michele M.
McMillan, Dayton
Liang, Xing
Finlay, Jarod C.
Busch, Theresa M.
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXIII, 2014, 8931
[2] In-vivo singlet oxygen threshold doses for PDT
Department of Radiation Oncology, University of Pennsylvania, TRC 4W, 3400 Civic Center Blvd, Philadelphia
PA
19104, United States
Photonics Lasers Med., 1 (59-71): : 59 - 71
[3] Exploring BODIPY Derivatives as Singlet Oxygen Photosensitizers for PDT
Prieto-Montero, Ruth
Prieto-Castaneda, Alejandro
Sola-Llano, Rebeca
Agarrabeitia, Antonia R.
Garcia-Fresnadillo, David
Lopez-Arbeloa, Inigo
Villanueva, Angeles
Ortiz, Maria J.
Moya, Santiago de la
Martinez-Martinez, Virginia
PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2020, 96 (03) : 458 - 477
[4] Macroscopic Modeling of the singlet oxygen production during PDT
Zhu, Timothy C.
Finlay, Jarod C.
Zhou, Xiaodong
Li, Jun
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XVI, 2007, 6427
[5] TOWARDS PDT SENSITIZERS WITH INTERNAL SOURCE OF SINGLET OXYGEN
FREYER, W
LEUPOLD, D
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1995, 30 (01) : 77 - 78
[6] A heterogeneous optimization algorithm for reacted singlet oxygen for interstitial PDT
Zhu, Timothy C.
Altschuler, Martin D.
Hu, Yida
Wang, Ken
Finlay, Jarod C.
Dimofte, Andreea
Cengel, Keith
Hahn, Stephen M.
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XIX, 2010, 7551
[7] In vivo PDT dosimetry: singlet oxygen emission and photosensitizer fluorescence
Lee, Seonkyung
Galbally-Kinney, Kristin L.
Murphy, Brian A.
Davis, Steven J.
Hasan, Tayyaba
Spring, Bryan
Tu, Yupeng
Pogue, Brian W.
Isabelle, Martin E.
O'Hara, Julia A.
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XIX, 2010, 7551
[8] Developments in PDT Sensitizers for Increased Selectivity and Singlet Oxygen Production
Mehraban, Nahid
Freeman, Harold S.
MATERIALS, 2015, 8 (07) : 4421 - 4456
[9] A feasibility study of singlet oxygen explicit dosmietry (SOED) of PDT by intercomparison with a singlet oxygen luminescence dosimetry (SOLD) system
Kim, Michele M.
Penjweini, Rozhin
Gemmell, Nathan R.
Veilleux, Israel
McCarthy, Aongus
Buller, Gerald
Hadfield, Robert H.
Wilson, Brian C.
Zhu, Timothy C.
OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXV, 2016, 9694
[10] In vivo singlet molecular oxygen measurements: Sensitive to changes in oxygen saturation during PDT
Looft, Andreas
Pfitzner, Michael
Preuss, Annegret
Roeder, Beate
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2018, 23 : 325 - 330

← 1 2 3 4 5 →