Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword

被引：18
|
作者：
Pollard, Patrick J. [2 ]
Kranc, Kamil R. [1 ]
机构：
[1] Univ Glasgow, Paul OGorman Leukaemia Res Ctr, Coll Med, Vet & Life Sci,Inst Canc Sci, Glasgow G12 0XB, Lanark, Scotland
[2] Univ Oxford, Oxford OX3 7BN, England
来源：
CELL STEM CELL | 2010年 / 7卷 / 03期
基金：
英国惠康基金;
关键词：
BIOLOGY; OXYGEN;
D O I：
10.1016/j.stem.2010.08.006
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Although hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et al. (2010) and Simsek et al. (2010) demonstrate that hypoxia regulates the metabolic state of HSCs and protects their integrity by controlling HIF-1 alpha.
引用
收藏
页码：276 / 278
页数：3
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