Research on new AMPA antagonists of 2,3-benzodiazepine type

被引：0
|
作者：
Sólyom, S [1 ]
机构：
[1] Inst Drug Res Ltd, Dept Chem Res, H-1045 Budapest, Hungary
来源：
PHARMAZIE | 2001年 / 56卷
关键词：
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In this review on the most interesting studies and discoveries made during our structure-activity relationship investigations with non-competitive AMPA antagonists of 2,3-benzodiazepine type, our chain of ideas is discussed which led to several new types of active non-competitive AMPA antagonists. Some selected compounds (e.g. GYKI-47261) exerting broad spectrum of anticonvulsive and excellent neuroprotective effects are being further investigated.
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页码：S62 / S66
页数：5
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