Copper-Catalyzed Oxidative 1,2-Alkylarylation of Styrenes with Unactivated C(sp3)-H Alkanes and Electron-Rich Aromatics via C(sp3)-H/C(sp2)-H Functionalization

被引：9

作者：

Jiang, Hui-Min ^{[1
]}

Sun, Qing ^{[1
]}

Jiang, Jin-Peng ^{[1
]}

Qin, Jing-Hao ^{[1
]}

Ouyang, Xuan-Hui ^{[1
]}

Song, Ren-Jie ^{[1
]}

机构：

[1] Nanchang Hangkong Univ, Key Lab Jiangxi Prov Persistent Pollutants Contro, Nanchang 330063, Jiangxi, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2022年 / 364卷 / 16期

基金：

中国国家自然科学基金;

关键词：

alkenes; copper-catalyzed; alkanes; C-H functionalization; SP(3) C-H; BOND FUNCTIONALIZATION; DIFUNCTIONALIZATION; ALKENES; DICARBOFUNCTIONALIZATION; ALKYLATION; ALKYNES; ACCESS; ALKYLARYLATION; ANNULATION;

D O I：

10.1002/adsc.202200548

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We have disclosed an alkenes dicarbofunctionalization method to introduce alkyl and electron-rich aryl across the C=C bond of styrenes under copper catalyst and oxidative conditions, leading to construct C(sp(3))-C(sp(2))/C(sp(3))-C(sp(3)) bonds via dual C-H functionalization. This method realizes the synthesis of 1,1-diarylalkanes, which are very important skeleton in natural products and drug molecules, through the grafting of electron-rich aromatics, including indoles, pyrroles, trisubstituted aromatic.

引用

页码：2772 / 2782

页数：11

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