Kashin-Beck disease and iodine deficiency in Tibet

被引：25

作者：

Moreno-Reyes, R ^{[1
]}

Suetens, C ^{[1
]}

Mathieu, F ^{[1
]}

Begaux, F ^{[1
]}

Zhu, D ^{[1
]}

Rivera, T ^{[1
]}

Boelaert, M ^{[1
]}

Nève, J ^{[1
]}

Perlmutter, N ^{[1
]}

Vanderpas, J ^{[1
]}

机构：

[1] Free Univ Brussels, Hop Erasme, Dept Nucl Med, B-1070 Brussels, Belgium

来源：

INTERNATIONAL ORTHOPAEDICS | 2001年 / 25卷 / 03期

关键词：

D O I：

10.1007/s002640000216

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.

引用

页码：164 / 166

页数：3

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