Transferrin receptor 2: Function and relevant disorders

被引：0

作者：

Chang, YZ

Duan, XL

Qian, ZM

机构：

[1] Hong Kong Polytech Univ, Lab Iron Metab, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[2] Hebei Normal Univ, Inst Neurobiol & Neuropharmacol, Shijiazhuang 050016, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2003年 / 30卷 / 04期

关键词：

iron metabolism; transferrin receptor 2; iron absorption; hereditory hemochormatosis (G51);

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transferrin receptor 2 (TfR2) is a newly discovered iron metabolism protein. New findings indicate that in addition to the ability of TfR2 to mediate iron uptake by the liver cells, TfR2 is important in regulation of iron absorption in the small intestine via controlling synthesis and release of hepcidin. The studies have also demonstrated that mutation in the human transferrin receptor 2 gene is one of the causes for hereditory hemochormatosis.

引用

页码：533 / 536

页数：4

共 26 条

[1] Experimental hemochromatosis due to MHC class IHFE deficiency:: Immune status and iron metabolism
Bahram, S
Gilfillan, S
Kühn, LC
Moret, R
Schulze, JB
Lebeau, A
Schümann, K
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (23) : 13312 - 13317
[2] Beutler Ernest, 1996, Blood Cells Molecules and Diseases, V22, P187, DOI 10.1006/bcmd.1996.0027
[3] The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
Camaschella, C
Roetto, A
Cali, A
De Gobbi, M
Garozzo, G
Carella, M
Majorano, N
Totaro, A
Gasparini, P
[J]. NATURE GENETICS, 2000, 25 (01) : 14 - 15
[4] Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
Deaglio, S
Capobianco, A
Calì, A
Bellora, F
Alberti, F
Righi, L
Sapino, A
Camaschella, C
Malavasi, F
[J]. BLOOD, 2002, 100 (10) : 3782 - 3789
[5] Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
Fleming, RE
Ahmann, JR
Migas, MC
Waheed, A
Koeffler, HP
Kawabata, H
Britton, RS
Bacon, BR
Sly, WS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (16) : 10653 - 10658
[6] Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
Fleming, RE
Migas, MC
Holden, CC
Waheed, A
Britton, RS
Tomatsu, S
Bacon, BR
Sly, WS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (05) : 2214 - 2219
[7] Mechanisms of iron accumulation in hereditary hemochromatosis
Fleming, RE
Sly, WS
[J]. ANNUAL REVIEW OF PHYSIOLOGY, 2002, 64 : 663 - 680
[8] Ferroportin mutation in autosomal dominant hemochromatosis: loss of function, gain in understanding
Fleming, RE
Sly, WS
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (04): : 521 - 522
[9] Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene
Girelli, D
Bozzini, C
Roetto, A
Alberti, F
Daraio, F
Colombari, R
Olivieri, O
Corrocher, R
Camaschella, C
[J]. GASTROENTEROLOGY, 2002, 122 (05) : 1295 - 1302
[10] Molecular cloning of transferrin receptor 2 - A new member of the transferrin receptor-like family
Kawabata, H
Yang, S
Hirama, T
Vuong, PT
Kawano, S
Gombart, AF
Koeffler, HP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) : 20826 - 20832

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