Stereoselective Synthesis of Polysubstituted Cyclopropanes from Poly(ethylene glycol) Supported Pyridinium Ylide

被引：0
|
作者：
Zhao Pan [1 ]
Lu Cui-fen [1 ]
Yang Gui-chun [1 ]
Chen Zu-xing [1 ]
Dong Nian-guo [2 ]
Shi Jia-wei [2 ]
机构：
[1] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Coll Chem & Chem Engn, Wuhan 430000, Peoples R China
[2] Huazhong Sci & Technol Univ, Dept Cardiovarscular Surg, Union Hosp, Tongji Med Coll, Wuhan 430072, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2011年 / 27卷 / 06期
基金：
国家高技术研究发展计划(863计划);
关键词：
Poly(ethylene glycol); Pyridinium ylide; Synthesis; Cyclopropane; TRANSFER-CATALYZED CONDITIONS; SOLUBLE SUPPORT; ORGANIC-SYNTHESIS; ASYMMETRIC CYCLOPROPANATION; DERIVATIVES; CIS-1-ARYL-2-BENZOYL-3,3-DICYANOCYCLOPROPANES; ELIMINATION; CYCLIZATION; LIBRARY; WATER;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Polysubstituted cyclopropanes were efficiently prepared with poly(ethylene glycol)(PEG) as soluble support. The reaction of PEG-supported pyridinium ylide with arylidenemalononitrilc(R=CN) or ethyl arylidenecyanoacetate(R=COOEt) in the presence of triethylamine(TEA) afforded PEG-supported cyclopropanecarboxylates, which were cleaved by 1% KCN/EtOH to obtain polysubstituted cyclopropanes with exclusive trans-selectivity and good yields.
引用
收藏
页码：984 / 987
页数：4
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