Enzymatic Membrane Reactor for Resolution of Ketoprofen in Ionic Liquids and Supercritical Carbon Dioxide

被引：0

作者：

Lozano, Pedro ^{[1
]}

De Diego, Teresa ^{[1
]}

Manjon, Arturo ^{[1
]}

Abad, Miguel A. ^{[1
]}

Vaultier, Michel

Iborra, Jose L. ^{[1
]}

机构：

[1] Univ Murcia, Fac Quim, Dept Bioquim & Biol Mol & Inmunol B, E-30100 Murcia, Spain

来源：

IONIC LIQUID APPLICATIONS: PHARMACEUTICALS, THERAPEUTICS, AND BIOTECHNOLOGY | 2010年 / 1038卷

关键词：

ANTARCTICA LIPASE-B; STABILITY; BIOCATALYSIS;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Ionic liquids (ILs) have attracted growing interest as alternative reaction media for enzyme-catalyzed transformations because of their unique properties as green solvents, opening up news opportunities in the field of pharmaceutical synthesis. Additionally, enzymatic transformations in ILs/scCO(2) biphasic systems have been described as an interesting way of carrying out clean synthetic processes whereby enzyme molecules are "immobilized" into the IL phase, while substrates/products are transported by the scCO(2) phase. Several ILs based on alkyl-imidazolium cations and associated with different anions, ([PF6], [BF4] and [NTf2]), have been assayed for the Candida antarctica lipase B (CALB)-catalyzed resolution of the analgesic rac-ketoprofen by esterification with different 1-alkanols. A membrane reactor working with both IL and supercritical carbon dioxide (scCO(2)) phases has been applied for separation of R-ketoprofen ester products.

引用

页码：25 / 34

页数：10

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