Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides

被引：64

作者：

Wu, Zhimeng ^{[1
]}

Guo, Xueqing ^{[1
]}

Guo, Zhongwu ^{[1
]}

机构：

[1] Wayne State Univ, Dept Chem, Detroit, MI 48202 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 32期

关键词：

PROTEIN LIGATION; ACIDS;

D O I：

10.1039/c1cc13322e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A chemoenzymatic method was developed for the synthesis of macrocyclic peptides and glycopeptides. Sortase A was found to mediate either head to tail cyclization or oligomerization and then head to tail cyclization of peptides and glycopeptides, depending on the peptide length, to produce 15-mer or higher cyclic peptides and glycopeptides.

引用

页码：9218 / 9220

页数：3

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