The hematopoietic stem cell niche

被引：49
|
作者：
Park, Dongsu [1 ,2 ,3 ,4 ]
Sykes, David B. [1 ,2 ,3 ,4 ]
Scadden, David T. [1 ,2 ,3 ,4 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
[3] Harvard Stem Cell Inst, Cambridge, MA 02138 USA
[4] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷
基金：
美国国家卫生研究院;
关键词：
Hematopoietic Stem Cells; Niche; Osteoblasts; Endothelial Cells; Review; COLONY-STIMULATING FACTOR; ACUTE MYELOID-LEUKEMIA; BONE-MARROW NICHE; CXCR4 ANTAGONIST AMD3100; PROGENITOR CELLS; IN-VIVO; SELF-RENEWAL; ENDOTHELIAL-CELLS; MOUSE MODEL; N-CADHERIN;
D O I：
10.2741/3913
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC niche is a goal of basic scientists and clinicians alike. Recent studies have focused on defining the cellular components and molecular factors critical to this microenvironment. Here we review recent findings, discuss unresolved questions, and examine the clinical implications of our current knowledge of the HSC niche.
引用
收藏
页码：30 / 39
页数：10
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