Base-promoted Lewis acid catalyzed synthesis of quinazoline derivatives

被引：9
|
作者：
Hu, Fang-Peng [1 ]
Cui, Xin-Feng [1 ]
Lu, Guo-Qiang [1 ]
Huang, Guo-Sheng [1 ]
机构：
[1] Lanzhou Univ, Dept Chem, State Key Lab Appl Organ Chem, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 23期
关键词：
ONE-POT SYNTHESIS; C-H AMINATION; O-AMINOBENZAMIDES; RUTHENIUM; FUNCTIONALIZATION; INHIBITORS; AMIDATION; REDUCTASE; CHEMISTRY; COMPOUND;
D O I：
10.1039/d0ob00225a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot protocol has been developed for the synthesis of quinazolinones from amide-oxazolines with TsClviaa cyclic 1,3-azaoxonium intermediate and 6 pi electron cyclization in the presence of a Lewis acid and base. The process is operationally simple and has a broad substrate scope. This method provides a unique strategy for the construction of quinazolinones.
引用
收藏
页码：4376 / 4380
页数：5
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