Immune Checkpoint Blockade in Lung Cancer

被引：0
|
作者：
Somasundaram, Aswin [1 ]
Socinski, Mark A. [1 ]
Villaruz, Liza C. [1 ]
机构：
[1] Univ Pittsburgh, Inst Canc, Div Hematol Oncol, Pittsburgh, PA 15232 USA
来源：
DISCOVERY MEDICINE | 2016年 / 22卷 / 119期
关键词：
UP-REGULATION; DOUBLE-BLIND; MULTICENTER; EXPRESSION; NIVOLUMAB; SAFETY; LYMPHOCYTES; DOCETAXEL; ANTIBODY; PHASE-2;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Immunotherapy has revolutionized the therapeutic landscape of advanced lung cancer. The adaptive immune system has developed a sophisticated method of tumor growth control, but T-cell activation is regulated by various checkpoints. Blockade of the immune checkpoints with therapies targeting the PD-1 pathway, such as nivolumab and pembrolizumab, has been validated as a therapeutic approach in non-small cell lung cancer. Newer therapies and novel combinations are also being evaluated, and the use of biomarkers in conjunction with these drugs is an area of active investigation. This review summarizes the current evidence for the efficacy and safety of the above approaches in the treatment of lung cancer.
引用
收藏
页码：56 / 66
页数：11
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