Transforming growth factor-β in tissue fibrosis

被引:545
|
作者
Frangogiannis, Nikolaos G. [1 ]
机构
[1] Albert Einstein Coll Med, Dept Med Cardiol, Wilf Family Cardiovasc Res Inst, Bronx, NY 10467 USA
来源
JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 03期
基金
美国国家卫生研究院;
关键词
TO-MESENCHYMAL TRANSITION; ACTIVATES LATENT TGF-BETA-1; ALVEOLAR EPITHELIAL-CELLS; HEPATIC STELLATE CELLS; SMOOTH-MUSCLE-CELLS; TGF-BETA; CARDIAC FIBROSIS; RENAL FIBROSIS; IN-VIVO; PULMONARY-FIBROSIS;
D O I
10.1084/jem.20190103
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
TGF-beta is extensively implicated in the pathogenesis of fibrosis. In fibrotic lesions, spatially restricted generation of bioactive TGF-beta from latent stores requires the cooperation of proteases, integrins, and specialized extracellular matrix molecules. Although fibroblasts are major targets of TGF-beta, some fibrogenic actions may reflect activation of other cell types, including macrophages, epithelial cells, and vascular cells. TGF-beta-driven fibrosis is mediated through Smad-dependent or non-Smad pathways and is modulated by coreceptors and by interacting networks. This review discusses the role of TGF-beta in fibrosis, highlighting mechanisms of TGF-beta activation and signaling, the cellular targets of TGF-beta actions, and the challenges of therapeutic translation.
引用
收藏
页数:16
相关论文
共 50 条
  • [1] Transforming growth factor-β and fibrosis
    Franck Verrecchia
    Alain Mauviel
    [J]. World Journal of Gastroenterology, 2007, (22) : 3056 - 3062
  • [2] Transforming growth factor-β and fibrosis
    Verrecchia, Franck
    Mauviel, Alain
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (22) : 3056 - 3062
  • [3] Transforming growth factor-β signaling: From tissue fibrosis to therapeutic opportunities
    Ren, Li-Li
    Li, Xiao-Jun
    Duan, Ting-Ting
    Li, Zheng-Hai
    Yang, Jun-Zheng
    Zhang, Ya-Mei
    Zou, Liang
    Miao, Hua
    Zhao, Ying-Yong
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 369
  • [4] Role of tissue transforming growth factor-β1 in pancreatic fibrosis.
    Shiozaki, M
    Takeda, Y
    Morikawa, H
    Nakagawa, Y
    Katsu, K
    [J]. GASTROENTEROLOGY, 1998, 114 (04) : A498 - A498
  • [5] Role and interaction of connective tissue growth factor with transforming growth factor-β in persistent fibrosis:: A mouse fibrosis model
    Mori, T
    Kawara, S
    Shinozaki, M
    Hayashi, N
    Kakinuma, T
    Igarashi, A
    Takigawa, M
    Nakanishi, T
    Takehara, K
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1999, 181 (01) : 153 - 159
  • [6] Integrated actions of transforming growth factor-β1 and connective tissue growth factor in renal fibrosis
    Qi, W
    Twigg, S
    Chen, X
    Polhill, TS
    Poronnik, P
    Gilbert, RE
    Pollock, CA
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 288 (04) : F800 - F809
  • [7] Transforming Growth Factor-β-Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis
    Sakai, Keiko
    Jawaid, Safdar
    Sasaki, Takako
    Bou-Gharios, George
    Sakai, Takao
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2014, 184 (10): : 2611 - 2617
  • [8] Hesperidin Prevents Liver Fibrosis in Rats by Decreasing the Expression of Nuclear Factor-κB, Transforming Growth Factor-β and Connective Tissue Growth Factor
    Perez-Vargas, J. Eliuth
    Zarco, Natanael
    Shibayama, Mineko
    Segovia, Jose
    Tsutsumi, Victor
    Muriel, Pablo
    [J]. PHARMACOLOGY, 2014, 94 (1-2) : 80 - 89
  • [9] Transforming growth factor-β1 and lung allograft fibrosis
    El-Gamel, A
    Awad, M
    Sim, E
    Hasleton, P
    Yonan, N
    Egan, J
    Deiraniya, A
    Hutchinson, IV
    [J]. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 1998, 13 (04) : 424 - 430
  • [10] Transforming Growth Factor-β and Angiotensin in Fibrosis and Burn Injuries
    Gabriel, Vincent Ashley
    [J]. JOURNAL OF BURN CARE & RESEARCH, 2009, 30 (03): : 471 - 481