Palladium-Catalyzed Direct ortho-C-H Acylation of 2-Phenylpyridine N-oxides with Benzyl Alcohols/α-Oxocarboxylic Acids

被引：2
|
作者：
Zhou, Ming-Dong [1 ]
Liu, Chang [1 ]
Sun, Jing [1 ]
Zhang, Jing-Hao [1 ]
Wang, He [1 ]
机构：
[1] Liaoning Shihua Univ, Sch Chem & Mat Sci, Fushun 113001, Peoples R China
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 47期
基金：
中国国家自然科学基金;
关键词：
Benzyl alcohols/alpha-oxocarboxylic acids; ortho-C-H acylation; Palladium catalysis; 2-Phenylpyridine N-oxides; ALPHA-KETO ACIDS; RELAY CATALYSIS; BOND ACYLATION; DERIVATIVES; CYCLIZATION; ARYLATION; AZOARENES; ETHERS;
D O I：
10.1002/slct.201904101
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A palladium(II)-catalyzed acylation of 2-phenylpyridine N-oxides via ortho-selective C-H activation at phenyl ring is developed using benzyl alcohols or alpha-oxocarboxylic acids as the acylation reagents under mild conditions. The two reaction protocols exhibited complementary substrate scopes, and are tolerated to a variety of 2-phenylpyridine N-oxide substrates with high yield and selectivity. Mechanism studies indicated that this acylation reaction includes a radical process via acyl radical.
引用
收藏
页码：13947 / 13951
页数：5
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