Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

被引：177

作者：

Haiman, Christopher A. ^{[1
]}

Chen, Gary K. ^{[1
]}

Blot, William J. ^{[2
,3
,4
]}

Strom, Sara S. ^{[5
]}

Berndt, Sonja I. ^{[6
]}

Kittles, Rick A. ^{[7
]}

Rybicki, Benjamin A. ^{[8
]}

Isaacs, William B. ^{[9
]}

Ingles, Sue A. ^{[1
]}

Stanford, Janet L. ^{[10
]}

Diver, W. Ryan ^{[11
]}

Witte, John S. ^{[12
,13
]}

Hsing, Ann W. ^{[6
]}

Nemesure, Barbara ^{[14
]}

Rebbeck, Timothy R. ^{[15
,16
]}

Cooney, Kathleen A. ^{[17
]}

Xu, Jianfeng ^{[18
]}

Kibel, Adam S. ^{[19
]}

Hu, Jennifer J. ^{[20
,21
]}

John, Esther M. ^{[22
]}

Gueye, Serigne M. ^{[23
]}

Watya, Stephen ^{[24
]}

Signorello, Lisa B. ^{[2
,3
,4
]}

Hayes, Richard B. ^{[25
]}

Wang, Zhaoming ^{[6
]}

Yeboah, Edward ^{[26
]}

Tettey, Yao ^{[26
]}

Cai, Qiuyin ^{[3
,4
]}

Kolb, Suzanne ^{[10
]}

Ostrander, Elaine A. ^{[27
]}

Zeigler-Johnson, Charnita ^{[15
,16
]}

Yamamura, Yuko ^{[5
]}

Neslund-Dudas, Christine ^{[8
]}

Haslag-Minoff, Jennifer ^{[19
]}

Wu, William ^{[19
]}

Thomas, Venetta ^{[20
,21
]}

Allen, Glenn O. ^{[20
,21
]}

Murphy, Adam ^{[28
]}

Chang, Bao-Li ^{[15
,16
]}

Zheng, S. Lilly ^{[14
]}

Leske, M. Cristina ^{[14
]}

Wu, Suh-Yuh ^{[14
]}

Ray, Anna M.

Hennis, Anselm J. M. ^{[14
,29
,30
,31
]}

Thun, Michael J. ^{[11
]}

Carpten, John ^{[32
]}

Casey, Graham ^{[1
]}

Carter, Erin N. ^{[1
]}

Duarte, Edder R. ^{[1
]}

Xia, Lucy Y. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA

[2] Int Epidemiol Inst, Rockville, MD USA

[3] Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA

[4] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[6] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[7] Univ Illinois, Dept Med, Chicago, IL USA

[8] Henry Ford Hosp, Dept Biostat & Res Epidemiol, Detroit, MI 48202 USA

[9] Johns Hopkins Hosp & Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD USA

[10] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[11] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[12] Univ Calif San Francisco, Inst Human Genet, Dept Epidemiol, San Francisco, CA 94143 USA

[13] Univ Calif San Francisco, Dept Biostat, San Francisco, CA 94143 USA

[14] SUNY Stony Brook, Dept Prevent Med, Stony Brook, NY 11794 USA

[15] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[16] Abramson Canc Ctr, Philadelphia, PA USA

[17] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI USA

[18] Wake Forest Univ, Sch Med, Ctr Canc Genom, Winston Salem, NC 27109 USA

[19] Washington Univ, Dept Surg, Div Urol, St Louis, MO USA

[20] Univ Miami, Miller Sch Med, Dept Epidemiol & Publ Hlth, Miami, FL 33136 USA

[21] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[22] Canc Prevent Inst Calif, Fremont, CA USA

[23] Hop Gen Grand Yoff, Dakar, Senegal

[24] Makerere Univ, Dept Surg, Urol Unit, Mulago Hosp, Kampala, Uganda

[25] NYU, Dept Environm Med, Langone Med Ctr, Div Epidemiol, New York, NY 10016 USA

[26] Univ Ghana, Sch Med, Legon, Ghana

[27] NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA

[28] Northwestern Univ, Dept Urol, Chicago, IL 60611 USA

[29] Univ W Indies, Fac Med Sci, Bridgetown, Barbados

[30] Univ W Indies, Chron Dis Res Ctr, Bridgetown, Barbados

[31] Minist Hlth, Bridgetown, Barbados

[32] Translat Genom Res Inst, Phoenix, AZ USA

[33] Univ Hawaii, Canc Res Ctr, Program Epidemiol, Honolulu, HI 96813 USA

来源：

NATURE GENETICS | 2011年 / 43卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MULTIPLE LOCI; RISK LOCUS; 8Q24; VARIANTS;

D O I：

10.1038/ng.839

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In search of common risk alleles for prostate cancer that could contribute to high rates of the disease in men of African ancestry, we conducted a genome-wide association study, with 1,047,986 SNP markers examined in 3,425 African-Americans with prostate cancer (cases) and 3,290 African-American male controls. We followed up the most significant 17 new associations from stage 1 in 1,844 cases and 3,269 controls of African ancestry. We identified a new risk variant on chromosome 17q21 (rs7210100, odds ratio per allele = 1.51, P = 3.4 x 10(-13)). The frequency of the risk allele is similar to 5% in men of African descent, whereas it is rare in other populations (<1%). Further studies are needed to investigate the biological contribution of this allele to prostate cancer risk. These findings emphasize the importance of conducting genome-wide association studies in diverse populations.

引用

页码：570 / U103

页数：6

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[1] Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
Christopher A Haiman
Gary K Chen
William J Blot
Sara S Strom
Sonja I Berndt
Rick A Kittles
Benjamin A Rybicki
William B Isaacs
Sue A Ingles
Janet L Stanford
W Ryan Diver
John S Witte
Ann W Hsing
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Stephen Watya
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William Wu
Venetta Thomas
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Adam Murphy
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